PMID: 3756534Sep 1, 1986Paper

The effects of neonatal monocular enucleation on the organization of ipsilateral and contralateral retinothalamic projections in the rabbit

Brain Research
A M GrigonisE H Murphy

Abstract

Autoradiographic methods were used to compare the ipsilateral and contralateral retinothalamic projections in pigmented Dutch-Belted rabbits that had neonatal monocular enucleation with the projections found in normally reared rabbits. In the normal adult rabbit, there is dense label throughout the dorsal lateral geniculate nucleus (LGd) except for a decreased label density in the region corresponding to the ipsilateral input. Following neonatal monocular enucleation, the contralateral projection fills in the part of the LGd corresponding to the ipsilateral input. Our data indicate that following monocular enucleation, two processes occur: an arrest of the segregation process and an expansion of the contralateral projection into the space normally containing the terminals of the ipsilateral projection. In addition, this filling in of the terminal space occurs relatively rapidly and is completed by day 14. No changes, however, were observed in the ipsilateral projection to the LGd. Unlike the LGd, the ventral lateral geniculate nucleus and the intergeniculate leaflet showed increases in the size of the ipsilateral projection region, and no changes in the contralateral projection. The present findings suggest that there may be di...Continue Reading

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Citations

Nov 1, 1989·Brain Research. Developmental Brain Research·N S GayerB Dreher
Jun 30, 1994·Behavioural Brain Research·P BarnéoudH Van der Loos
Sep 1, 1990·The Journal of Comparative Neurology·J W Crabtree
Aug 28, 1995·The Journal of Comparative Neurology·A M Harman, G Jeffery
Dec 10, 2013·NeuroImage. Clinical·Krista R KellyJennifer K E Steeves
Oct 1, 2017·Human Brain Mapping·Nikita A WongJennifer K E Steeves

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