The effects of neuroleptic drugs on 5-hydroxytryptamine induced platelet aggregation in schizophrenic patients

British Journal of Clinical Pharmacology
M W OrrD G Grahame-Smith

Abstract

1 The effects of treatment with a range of neuroleptic drugs on 5-hydroxytryptamine (5-HT) induced platelet aggregation in vivo were examined in a group of recently admitted psychiatric patients and in a larger group of chronic schizophrenic patients. 2 Five of seven recently admitted patients treated with chlorpromazine showed enhanced aggregation. Four of seven patients treated with fluphenazine, flupenthixol, trifluoperazine and haloperidol showed enhancement. 3 Enhanced aggregation responses were observed in only 20% of chronic schizophrenic patients being treated with a neuroleptic drug. 4 The relationship between changes in platelet aggregation and clinical changes in recently admitted patients was variable and platelet aggregation responses were not predictive of response to treatment. 5 Chronic schizophrenic patients with enhanced aggregation showed significant week to week variation in platelet aggregation response. Variability of responses was not related to the drug used or to the dose administered. There was some evidence that higher plasma concentrations of neuroleptic drugs were associated with enhanced platelet aggregation responses. 6 Treatment with neuroleptic drugs leads to enhancement of platelet aggregation ...Continue Reading

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Citations

Jul 20, 2002·Psychiatry Research·Kazuhiko ToyookaHiroyuki Nawa
Jun 30, 2007·Clinical and Experimental Pharmacology & Physiology·Stina AxelssonPer A Whiss
Dec 7, 2011·British Journal of Clinical Pharmacology·Jeffrey K Aronson
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Mar 17, 2007·Toxicologic Pathology·Yuval Ramot, Abraham Nyska
Sep 18, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Christopher A Paciullo
Sep 21, 2013·Journal of Clinical Psychopharmacology·Niklas Schmedt, Edeltraut Garbe
Oct 26, 2013·Journal of Clinical Psychopharmacology·Pietro GareriGiovambattista De Sarro
Apr 24, 2013·Journal of Clinical Psychopharmacology·Pei-Hua HsiehChurn-Shiouh Gau
Oct 18, 2002·CNS Drugs·Staffan Hägg, Olav Spigset
Mar 1, 1981·British Journal of Clinical Pharmacology·A V Mackay

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