The effects of neuropeptide Y on myocardial contractility and coronary blood flow

British Journal of Pharmacology
S J AwadD P Richardson

Abstract

1. This study was designed to assess the effects of exogenous neuropeptide Y (NPY) on cardiac contractility and coronary blood flow (CBF) in anaesthetized dogs and to evaluate the effect of NPY on the responses to sympathetic and parasympathetic stimulation and to inotropic agents. 2. Bolus doses of NPY (500 micrograms), administered via the femoral vein, increased mean arterial pressure. The pressor effect was associated with reductions in heart rate, CBF and cardiac contractility. 3. The effects of NPY (500 micrograms) on contractility and CBF were compared with that of vasopressin (VP) (1 unit). For similar reductions in CBF, NPY and VP had similar negative inotropic effects. Thus, it is likely that the negative inotropic response to NPY is not due to a direct effect of NPY on the heart muscle but is largely due to coronary vasoconstriction. 4. In the presence of NPY (500 micrograms, i.v.), there was an inhibition of the positive inotropic response to stimulation of the left cardiac sympathetic nerve (2 or 5 Hz, 0.05 ms). NPY also inhibited the negative inotropic response and chronotropic response to vagal stimulation (2, 3 or 5 Hz, 0.05 ms). 5. Dose-response curves were obtained for the inotropic, chronotropic and pressor r...Continue Reading

References

Jun 1, 1987·Journal of Cardiovascular Pharmacology·C Han, P W Abel
Sep 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·H M PiperB J McDermott
Oct 1, 1987·British Journal of Pharmacology·R EinsteinD P Richardson
Jan 1, 1988·Pharmacology & Therapeutics·E K Potter
Jul 1, 1988·The American Journal of the Medical Sciences·C J TsengR M Robertson
Apr 1, 1987·Acta Physiologica Scandinavica·C WahlestedtR Håkanson
Mar 1, 1987·Clinical and Experimental Pharmacology & Physiology·R B MinsonJ P Chalmers
Mar 1, 1986·Acta Physiologica Scandinavica·J M AllenS R Bloom
Jun 1, 1985·Japanese Circulation Journal·Y AizawaA Shibata
Jul 1, 1972·Medical & Biological Engineering·A H GoodmanL B Cobbin
Sep 1, 1966·Circulation Research·M N LevyH Zieske
Sep 1, 1984·The Journal of Physiology·G P CourticeE K Potter
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·M A PettyR E Lang
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J M LundbergL Terenius
Oct 1, 1984·British Journal of Pharmacology·L EdvinssonC Wahlestedt

Citations

Mar 1, 1992·Journal of the Autonomic Nervous System·E K PotterD I McCloskey
Nov 19, 1993·Regulatory Peptides·P M MertesM Boulangé
Feb 24, 2011·Obstetrics and Gynecology·Joseph E PotterDaniel Grossman
Aug 25, 2001·American Journal of Obstetrics and Gynecology·J La Valleur, S Wysocki
Jun 16, 1999·American Journal of Obstetrics and Gynecology·V I RickertC M Wiemann
Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Danielle JacquesChantale Provost
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fang XieJing Ai
May 1, 1996·Journal of Cardiovascular Pharmacology·A S TadepalliA J Daniels

Related Concepts

Proventil
Metazoa
Diastolic Blood Pressure
Coronary Circulation
Oxiken
Canis familiaris
Dose-Response Relationship, Drug
Electric Stimulation Technique
Guanidines
Pulse Rate

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.