The effects of nicotine dependence and acute abstinence on the processing of drug and non-drug rewards

Psychopharmacology
W LawnH Valerie Curran

Abstract

Drug addiction may be characterised by a hypersensitivity to drug rewards and a hyposensitivity to non-drug rewards. This imbalance may become further polarised during acute abstinence. (i) Examine the differences between dependent and occasional smokers in choices for, motivation for and self-reported wanting and liking of cigarette and non-drug rewards. (ii) Examine the effects of 12-h nicotine abstinence on these metrics. Dependent (n = 20) and occasional, non-dependent smokers (n = 20) were tested after ad libitum smoking and ≥12-h of nicotine abstinence. A novel task was developed (Drug, Reward and Motivation-Choice (DReaM-Choice)) in which different rewards (cigarettes, music and chocolate) could be won. In each trial, participants chose between two rewards and then could earn the chosen reward via repeated button-pressing. Participants subsequently 'consumed' and rated subjective liking of the rewards they had won. Compared with occasional smokers, dependent smokers made more choices for (p < 0.001), pressed more for (p = 0.046) and reported more wanting (p = 0.007) and liking (p < 0.001) of cigarettes, and also made fewer choices for chocolate (p = 0.005). There were no differences between the groups on button-pressing ...Continue Reading

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Citations

Oct 30, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Erica N GrodinReza Momenan
Apr 4, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jason A OliverDavid J Drobes
May 10, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Nicolas J Schlienz, Larry W Hawk
May 10, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John R HughesJeff Priest
Feb 7, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John R HughesCatherine Peasley-Miklus
Nov 21, 2020·Journal of Psychiatry and Brain Science·Daniel SazhinDavid V Smith

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