The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus.

Brain Research
Sheila V KusnoorAriel Y Deutch

Abstract

Neuronal loss in Parkinson's disease (PD) is seen in a number of brain regions in addition to the substantia nigra (SN). Among these is the thalamic parafascicular nucleus (PF), which sends glutamatergic projections to the striatum and receives GABAergic inputs from the SN. Recent data suggest that lesions of nigrostriatal dopamine axons cause a loss of PF neurons, which has been interpreted to suggest that the PF cell loss seen in PD is secondary to dopamine denervation. However, the extent of a PF dopamine innervation in the rat is unclear, and it is possible that PF cell loss in parkinsonism is independent of nigrostriatal dopamine degeneration. We characterized the dopamine innervation of the PF in the rat and determined if 6-hydroxydopamine SN lesions cause PF neuron degeneration. Dual-label immunohistochemistry revealed that almost all tyrosine hydroxylase-immunoreactive (TH-ir) axons in the PF also expressed dopamine-beta-hydroxylase and were therefore noradrenergic or adrenergic. Moreover, an antibody directed against dopamine revealed only very rare PF dopaminergic axons. Retrograde-tract tracing-immunohistochemistry did not uncover an innervation of the PF from midbrain dopamine neurons. Nigrostriatal dopamine neuron ...Continue Reading

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Citations

Oct 7, 2015·Frontiers in Neuroanatomy·Rosa M VillalbaYoland Smith
Jul 11, 2014·Frontiers in Neural Circuits·Carmen Varela
Jul 6, 2017·The European Journal of Neuroscience·Asami TanimuraDalton James Surmeier
Feb 3, 2016·Journal of Neurotrauma·Li-Qun RenMengliang Zhang

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