The effects of non-steroidal anti-inflammatory drugs on cholinergic and histamine-induced contractions of guinea-pig isolated ileum

British Journal of Pharmacology
J P FamaeyJ Reuse

Abstract

1 Eleven non-steroidal anti-inflammatory drugs (NSAID) reversibly inhibited contractions of the longitudinal muscle of the guinea pig isolated ileum induced by acetylcholine, histamine, electrical transmural stimulation and nicotine in this order of increasing potency. 2. After the addition of prostaglandins E1, E2 or F2alpha, with partially effective concentrations of NSAID (but not with higher concentrations which almost totally prevented the responses) the inhibitory effects of NSAID were reversibly lost, except for electrically induced contractions and prostaglandin F2alpha. 3 The effects of NSAID may be due to actions on biological membranes or on distribution of ions in addition to their inhibitory effect on prostaglandin synthesis. Prostaglandins may reverse the inhibition by non-selective sensitization of smooth muscle to various agonists.

References

Oct 1, 1976·Archives internationales de physiologie et de biochimie·J P Famaey, M W Whitehouse
Aug 1, 1975·Seminars in Arthritis and Rheumatism·J P FamaeyW C Dick
Feb 1, 1973·The Journal of Pharmacy and Pharmacology·E K Chong, O A Downing
Aug 1, 1974·British Journal of Pharmacology·O KadlecI Seferna
Nov 1, 1967·British Journal of Pharmacology and Chemotherapy·B J Northover
Jul 1, 1972·British Journal of Pharmacology·A Eckenfels, J R VANE
Jan 1, 1966·Annual Review of Pharmacology·C A Winter
Nov 1, 1968·British Journal of Pharmacology·A BennettG B Scholes
Mar 31, 1959·Acta Physiologica Scandinavica·S BERGSTROMJ SJOVALL
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·M DAY, J R VANE
Aug 27, 1964·Annals of the New York Academy of Sciences·W G SPECTOR, D A WILLOUGHBY
Jan 1, 1962·The American Journal of Physiology·R W SCHAYER

Citations

Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·J FontaineJ Reuse
Jul 1, 1979·European Journal of Pharmacology·W DiamantisV B Ciofalo
Apr 1, 1991·The Journal of Pharmacy and Pharmacology·C H Cho, G W Teh
Oct 20, 2001·Biological & Pharmaceutical Bulletin·K SatohH Sasaki
Feb 1, 1979·Archives internationales de physiologie et de biochimie·C TsiamitasJ Dozi-Vassiliades
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Serio, E E Daniel
Jul 1, 1984·The Journal of Pharmacy and Pharmacology·J FontaineJ Reuse
Feb 1, 1980·The Journal of Pharmacy and Pharmacology·H SatoH Hikino
Apr 1, 1980·The Journal of Pharmacy and Pharmacology·J FontaineJ Reuse

Related Concepts

Acetilcolina Cusi
Metazoa
Anti-Inflammatory Agents
Drug Interactions
Electric Stimulation Technique
Cavia porcellus
Ceplene
Ileum
Inotropism
Smooth Muscle

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.