The effects of normovolemic anemia and blood transfusion on cerebral microcirculation after severe head injury

Intensive Care Medicine Experimental
Judith BellapartJohn Fraser


Cerebral regional microcirculation is altered following severe head injury. In addition to tissue disruption, partial pressure of tissue oxygenation is impaired due to an increase in the oxygen tissue gradient. The heterogenic distribution of cerebral microcirculation is multifactorial, and acute anemia challenges further the delivery of oxygen to tissues. Currently, a restrictive transfusion threshold is globally applied; however, it is unclear how anemia modifies regional cerebral microcirculation; hence, it is unclear if by aiming to a global endpoint, specific anatomical regions undergo ischemia. This study aims to quantify the temporal changes in cerebral microcirculation after severe head injury, under the effect of anemia and transfusion. It also aims to assess its effects specifically at the ischemic penumbra compared to contralateral regions and its interactions with axonal integrity in real time. Twelve ovine models were subjected to a severe contusion and acceleration-deceleration injury. Normovolemic anemia to a restrictive threshold was maintained after injury, followed by autologous transfusion. Direct quantification of cerebral microcirculation used cytometric count of color-coded microspheres. Axonal injury was ...Continue Reading


Sep 1, 1978·Respiration Physiology·M Samaja, L Gattinoni
Mar 1, 1987·The Journal of Trauma·J B FortuneD M Shah
Sep 29, 1998·Critical Care Medicine·Alex ValadkaClaudia S Robertson
Mar 9, 2000·Critical Care Medicine·Daniel L Traber
Mar 23, 2000·Cardiovascular Research·F W Prinzen, J B Bassingthwaighte
Jun 21, 2002·Transfusion Medicine Reviews·Jeffrey L CarsonDavid Henry
Oct 19, 2002·Current Opinion in Critical Care·Andrew J Johnston, Arun K Gupta
Jun 10, 2004·Critical Care Medicine·David K MenonJohn D Pickard
Nov 4, 2005·Journal of Neurosurgery·Michael F StiefelAnthony Marmarou
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Ibolja Cernak
Jun 9, 2007·Journal of Applied Physiology·Gregory M T HareAndrew J Baker
Jun 19, 2007·British Journal of Anaesthesia·C Werner, K Engelhard
Feb 21, 2009·Neurological Research·Tatsuki ItohHiroyuki Ito
Mar 31, 2009·Ultrasound in Medicine & Biology·Judith Bellapart, John Fraser
Oct 7, 2009·Journal of Neurotrauma·Susanne M SchwarzmaierNikolaus Plesnila
Jul 4, 2012·Annals of Internal Medicine·Jeffrey L CarsonClinical Transfusion Medicine Committee of the AABB
Aug 28, 2012·The Journal of Trauma and Acute Care Surgery·Judith BellapartJohn Fraser
Sep 3, 2013·Vox Sanguinis·G SimonovaY L Fung
Jul 25, 2014·JAMA : the Journal of the American Medical Association·Claudia S RobertsonPaul Swank
Feb 13, 2016·Frontiers in Neurology·Judith BellapartJohn Fraser

Related Concepts

Blood Transfusion
Blood Transfusion, Autologous
Complete Blood Count
Patient Care
Craniocerebral Trauma

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.