PMID: 1201614Dec 1, 1975Paper

The effects of O-acetylsterigmatocystin and related compounds on rat liver and cultured chicken embryonal liver cells

Chemico-biological Interactions
K TeraoM Yamazaki

Abstract

Fine structural nucleolar changes induced in rat liver and primary tissue culture cells from 10-day-old chicken embryonal liver by O-acetylsterigmatocystin (AcO-stg), related compounds and aflatoxin B1 were compared. (1) Male Wistar rats were given a single i.p. injection of sterigmatocystin (stg), AcO-stg, and aflatoxin B1. 3 days after the injection of 15 mg/kg of stg, sporadic single cell necrosis was observed in rat liver, whereas rats treated with 8 mg/kg AcO-stg or more, and 3 mg/kg of aflatoxin B1 showed massive liver necrosis. Acetylation resulted in a marked increase in solubility in polar organic solvents. This increased solubility could play an important role in determining toxicity. (II) Treatment with the compounds with an unsaturateddelta1,2-furobenzofuranring system, such as AcO-stg, demethyl-diacetyl-stg (deMe-diAc-stg), and aflatoxin B1, resulted in nucleolar segregation and fragmentation of primary culture cells. Both parenchymal and mesenchymal cells in culture were susceptible to AcO-stg and deMe-diAc-stg, while the mesenchymal cells were more resistant to aflatoxin B1 than the hepatocytes. The inhibition of RNA synthesis in both cell types as determined in radioautography was in accordance with the electron...Continue Reading

References

Dec 1, 1968·Food and Cosmetics Toxicology·I F Purchase, J J van der Watt
Jan 1, 1972·Annual Review of Microbiology·M Enomoto, M Saito
Oct 1, 1973·Toxicology and Applied Pharmacology·I F Purchase, J J Van der Watt
Oct 1, 1967·Experimental Cell Research·K Terao
Mar 1, 1969·Food and Cosmetics Toxicology·I F Purchase, J J van der Watt

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Citations

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J M EssigmannG N Wogan
Dec 10, 2009·Molecular Nutrition & Food Research·Aleksandrs Versilovskis, Sarah De Saeger

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