The effects of oral and intravenous direct thrombin inhibitors on the size of photochemically induced cortical infarction in rats

Thrombosis Research
A MikulskiD Gustafsson

Abstract

Oral thrombin inhibitors are under development as potential drugs for prophylaxis and treatment of thrombotic events. The effect of pretreatment with two direct thrombin inhibitors, melagatran and inogatran, was evaluated in a rat model of cerebral infarction. Ischaemic stroke was induced by photochemical reaction after an injection of Rose Bengal and focused posterior and to the right of the intersection of the coronal and sagittal sutures on the intact calvarium. A single oral dose of melagatran (30 micromol/kg) significantly reduced the volume of the cortical infarct by 53% (P<.05) compared with control. In addition, following intravenous inogatran (6 micromol/kg) or oral inogatran (100 micromol/kg), the volume of the cortical infarct decreased by 83% and 19%, respectively, compared with control. This study showed that experimental focal ischaemic infarction, elicited by photochemically induced endothelial cell damage, can be significantly reduced with melagatran and inogatran, direct thrombin inhibitors.

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Citations

Nov 5, 2003·CNS Drugs·Geoffrey A DonnanStephen M Davis
Apr 22, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·M HellgrenK Wåhlander
Sep 17, 2003·Journal of Internal Medicine·D Gustafsson
Jul 28, 2016·Journal of Cellular Physiology·Safieh EbrahimiSeyed Mahdi Hassanian
Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Murat KarabiyikogluGuohua Xi
Oct 1, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Susanne JohanssonUlf G Eriksson

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