PMID: 7535836Feb 1, 1995Paper

The effects of ovine placental lactogen infusion on metabolites, insulin-like growth factors and binding proteins in the fetal sheep

The Journal of Endocrinology
M H OliverP Gluckman

Abstract

It has been suggested, but not shown, that in the fetus placental lactogen (PL) may affect the regulation of the IGFs and fetal metabolism. To examine the effects of PL on the circulating concentrations of the IGFs, IGF-binding proteins (IGFBPs), glucose, free fatty acids (FFAs) and amino nitrogen (AN), we infused late gestation sheep fetuses with recombinant ovine PL (roPL). Five chronically-catheterised sheep fetuses were infused intravenously with three 24 h infusions of saline, roPL (100 micrograms bolus then 500 micrograms over 24 h) and then saline again. Fetal roPL infusion increased plasma oPL from 0.4 +/- 0.1 to 3.3 +/- 0.5 nM (mean +/- S.E.M.; P < 0.05; factorial analysis of variance and Scheffé's test). Fetal plasma IGF-I, IGF-II, insulin, FFAs and blood glucose were unaffected by the roPL infusion. Fetal plasma IGFBP-3, as measured by Western ligand blotting, decreased by 30% during fetal roPL infusion while other fetal plasma IGFBPs were unaffected. Fetal roPL infusion decreased fetal blood AN from 7.3 +/- 0.5 to 6.6 +/- 0.2 mM (P < 0.05). Maternal plasma IGF-I, IGF-II, IGFBPs, insulin, FFAs, blood glucose and AN were unaffected by the fetal roPL infusion. Saline infusion had no effect on any parameter. The data su...Continue Reading

Citations

Nov 12, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Stéphane OstrowskiHelga Sauerwein
Aug 29, 1998·Molecular and Cellular Endocrinology·M K BauerP D Gluckman
Nov 1, 1996·Domestic Animal Endocrinology·P A SchoknechtA W Bell
Feb 5, 2010·Acta Veterinaria Scandinavica·Andrea Vivian Alvarez-OxileyJean-François Beckers
Dec 24, 1997·Acta Paediatrica. Supplement·J E HardingR M Kimble
Dec 24, 1997·Acta Paediatrica. Supplement·P D Gluckman
Jul 24, 2004·Animal Reproduction Science·E Gootwine
Sep 6, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Erica J Crespi, Robert J Denver
Nov 6, 2009·Obstetrics and Gynecology·Anne L JaquieryJane E Harding
Jun 2, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M L BarrazaJ L Klotz
May 25, 2006·American Journal of Physiology. Endocrinology and Metabolism·Ilham El KhattabiBrigitte Reusens
Aug 8, 2021·International Journal of Molecular Sciences·Amelia R TannerRussell V Anthony

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