PMID: 2107502Feb 1, 1990Paper

The effects of oxytetracycline on Theileria parva in vitro

Parasitology
P R Spooner

Abstract

When bovine peripheral blood leucocytes were infected with Theileria parva sporozoites, immediate treatment with oxytetracycline (OTC) inhibited the development of sporozoites to mature schizonts. The extent of inhibition was dependent on drug concentration and duration of treatment. Concentrations of 5 micrograms/ml OTC, or higher, for 8 days completely inhibited the establishment of schizonts and their ability to transform host cells. A cytostatic effect on schizont-infected cell lines was found with three tetracyclines and was also demonstrated on uninfected lymphoblasts. The parasites were found to be sensitive to OTC during development to schizonts, but when mature and established within host cells, schizonts were not demonstrably affected. The infectivity of sporozoites and the binding of sporozoites to lymphocytes were not directly inhibited by OTC. The results may explain the action of tetracyclines when used prophylactically during immunization against East Coast fever, and also the reasons for the ineffectiveness of these drugs when used therapeutically during patent disease.

References

Jan 1, 1977·Advances in Parasitology·R E Purnell
Jun 24, 1976·Nature·N McHardyT T Dolan
Dec 1, 1976·Parasitology·J F Ryley, R G Wilson
Aug 1, 1985·Experimental Parasitology·D A DobbelaereA D Irvin
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·P LelieveldL M van Putten
May 1, 1973·The Journal of protozoology·M P CunninghamJ D Dargie
Jul 1, 1966·Journal of Comparative Pathology·S J Ball, E W Warren
Jan 3, 1953·Nature·W O NEITZ

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Citations

Jul 1, 1995·Parasitology·S P MorzariaP R Spooner
Aug 1, 1994·Veterinary Parasitology·A S Peregrine
Jan 13, 2009·Trends in Parasitology·Giuseppe Di GiulioRichard Bishop
Oct 30, 2016·Trends in Parasitology·Christopher D GoodmanStuart A Ralph
Oct 2, 2019·Infection and Immunity·Reginaldo G BastosLindsay M Fry

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