The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021

Pharmacological Research Communications
J BaranesP Braquet

Abstract

BN 52021, a new specific PAF-acether receptor antagonist, was evaluated on several cardiovascular models. BN 52021 antagonized PAF-acether-induced extravasation in rats. Inhibition of the hypotensive action of PAF-acether was obtained by administration of the antagonist, given preventively or curatively. In isolated guinea-pig hearts, BN 52021 inhibited the vasoconstriction induced by PAF-acether whereas a small inhibition was observed with papaverine. On the other hand, phosphodiesterase inhibitors were very effective against coronary vasoconstriction induced by vasopressin while BN 52021 was without effect. PAF-acether increased the tonus of rat isolated portal vein; this effect was inhibited by BN 52021, without any reduction in basal myogenic activity. In this model Ca2+ antagonists (D 600, diltiazem) showed a small inhibitory effect but they strongly reduced basal myogenic activity. Neither PAF-acether nor BN 52021 modified phenylephrine-induced contraction of the isolated rabbit aorta with or without endothelium demonstrating that endothelium-dependent relaxing factor is not related to PAF-acether. Our results suggest that BN 52021 specifically block the cardiovascular effects of PAF-acether. This agent may thus be an use...Continue Reading

References

Jun 28, 1979·Nature·M ChignardJ Benveniste
Jun 29, 1985·Lancet·U BengtssonS Carlsson
Apr 30, 1985·Biochemical and Biophysical Research Communications·S B HwangT Y Shen
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Dec 1, 1982·Agents and Actions·C G CaillardL Julou
Jan 1, 1981·Annals of the New York Academy of Sciences·B B VargaftigF Wal
Oct 1, 1981·Pharmacological Research Communications·J C Gomes, A Antonio

❮ Previous
Next ❯

Citations

Dec 1, 1991·Lipids·R RabinoviciG Feuerstein
Mar 1, 1987·Prostaglandins, Leukotrienes, and Medicine·P BraquetJ J Godfroid
Apr 12, 2001·Journal of Ethnopharmacology·I JantanN A Warif
Mar 1, 1997·Journal of Lipid Mediators and Cell Signalling·G FeuersteinS Vonhof
Jan 1, 1990·British Journal of Clinical Pharmacology·J H WilkensJ C Frölich
Mar 1, 1990·Agents and Actions·Y DenizotJ Benveniste
May 1, 1991·Journal of Veterinary Internal Medicine·D D Morris
Mar 3, 2005·Phytotherapy Research : PTR·Ibrahim JantanJuriyati Jalil
Jun 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Y JeremyD P Mikhailidis
Jan 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M Evangelou
Apr 14, 1989·Biochemical and Biophysical Research Communications·M T DomingoP Braquet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.