The Effects of Parenteral Amino Acid Therapy on Protein Carbamylation in Maintenance Hemodialysis Patients

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Sahir KalimAnders H Berg

Abstract

Protein carbamylation is a urea-driven post-translational protein modification associated with mortality in dialysis patients. Free amino acids (AAs) are competitive inhibitors of protein carbamylation and animal studies suggest increasing AA concentrations reduces carbamylation burden. We hypothesized that AA therapy in maintenance hemodialysis patients would reduce carbamylation, carrying the potential to improve clinical outcomes. Prospective pilot clinical trial (NCT1612429). The study was conducted from March 2013 to March 2014 in outpatient dialysis facilities in the Boston metropolitan area. We enrolled 23 consecutively consenting hemodialysis subjects, infusing the first 12 individuals with 250 cc of AAs 3 times per week postdialysis over 8 weeks. The remaining 11 subjects served as controls. Change in carbamylated albumin (C-Alb), a measure of total body carbamylation burden, between baseline and 8 weeks was the primary outcome. The treated and control groups had similar clinical characteristics and similar baseline C-Alb levels (mean ± SE 9.5 ± 2.4 and 9.3 ± 1.3 mmol/mol, respectively; P = .61). The treated arm showed a significant reduction in C-Alb compared with controls at 4 weeks (8.4% reduction in the treated arm...Continue Reading

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Citations

Jun 11, 2015·Kidney International·Frederik H VerbruggeStanley L Hazen
Jun 23, 2016·Hemodialysis International·Jeffrey PerlAnders H Berg
Jul 23, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sahir KalimAnders H Berg
Mar 16, 2018·IUBMB Life·Asim BadarKhursheed Alam
Feb 3, 2016·Circulation·Marcello TonelliRavi Thadhani
Aug 28, 2018·Current Opinion in Nephrology and Hypertension·Sahir Kalim
Mar 23, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Caitlin TrottierSahir Kalim
Aug 2, 2017·Nature Reviews. Nephrology·Sigurd DelangheMarijn M Speeckaert
May 12, 2021·Nature Reviews. Nephrology·Heidi NoelsJoachim Jankowski
Apr 3, 2020·Current Vascular Pharmacology·Athanasios RoumeliotisAndreas Pierratos
Aug 31, 2021·Nutrition·Nara Aline CostaMarcos Ferreira Minicucci
Sep 15, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincent VerdierLaetitia Koppe
Oct 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Yuhao MaLarry Unsworth

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