The effects of pargyline on overflow of transmitter and uptake of noradrenaline in the cat spleen

British Journal of Pharmacology
A G BlakeleyR J Summers

Abstract

1. Twenty minutes after the addition of pargyline (5 x 10(-4)M) to blood perfusing the isolated spleen of the cat, the overflow of transmitter resulting from stimulation of the sympathetic nerves increased 2.3-3-fold. Lower doses of pargyline did not significantly affect overflow.2. Monoamine oxidase activity, measured with either radioactively labelled tyramine or noradrenaline as substrate, was almost completely inhibited by doses of pargyline in the range of 10(-4)M to 5 x 10(-4)M. Inhibition of enzyme activity was not correlated with the effect on overflow. Pargyline had only a slight inhibitory effect on catechol-O-methyl transferase.3. Uptake of a 1 mug injection (pulse) of labelled noradrenaline, following pargyline (5 x 10(-4)M), was increased to 199.1% of that found in control experiments.4. Pargyline significantly reduced the vascular responses to nerve stimulation but had no significant effect on capsular responses.5. The inhibitor had no effect on resting overflow of labelled noradrenaline from the spleen but doubled the overflow of labelled noradrenaline following nerve stimulation.6. It is suggested that the effect of pargyline on overflow is due to increased release of transmitter during nerve stimulation.7. The ...Continue Reading

References

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K StarkeH J Schümann
Apr 1, 1972·British Journal of Pharmacology·M A EneroF J Stefano
Nov 15, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J S Gillespie
Oct 7, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A G BlakeleyL B Geffen
Dec 23, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A G BlakeleyR I Woods
Apr 1, 1971·British Journal of Pharmacology·L L Iversen
Nov 1, 1970·British Journal of Pharmacology·L L Iversen, P J Salt
Aug 29, 1957·The Journal of Physiology·G L BROWN, J S GILLESPIE
Jul 1, 1964·Biochemical Pharmacology·S OTSUKA, Y KOBAYASHI
Jan 1, 1965·The Journal of Physiology·J S GILLESPIE, S M KIRPEKAR
Jun 15, 1949·The Journal of Physiology·J H GaddumM Vogt

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Citations

Feb 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T J Verbeuren, P M Vanhoutte
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Mar 1, 1973·British Journal of Pharmacology·G Powis
Apr 1, 1977·British Journal of Pharmacology·A G Blakeley, R J Summers

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