PMID: 9430774Feb 7, 1998Paper

The effects of pentoxifylline infusion on plasma 6-keto-prostaglandin F1 alpha and ex vivo endotoxin-induced tumour necrosis factor activity in horses

Journal of Veterinary Pharmacology and Therapeutics
M H BartonJ N Moore

Abstract

Pentoxifylline (7.5 mg/kg) was bolused intravenously to eight healthy horses and was immediately followed by infusion (1.5 mg/kg/h) for 3 h. Clinical parameters were recorded and blood samples were collected for 24 h. Plasma was separated and concentrations of pentoxifylline, its reduced metabolite I, and 6-keto-prostaglandin F1 alpha were determined. Heparinized whole blood was also incubated ex vivo with 1 ng Escherichi coli endotoxin/mL blood for 6 h before determination of plasma tumour necrosis factor activity. The peak plasma concentrations of pentoxifylline and metabolite I occurred at 15 min after bolus injection and were 9.2 +/- 1.4 and 7.8 +/- 4.3 micrograms/mL, respectively. The half-life of elimination (t1/2 beta) of pentoxifylline was 1.44 h and volume of distribution (Vdarea) was 0.94 L/kg. The mean plasma concentration of 6-keto-prostaglandin F1 alpha increased over time, with a significant increase occurring 30 min after the bolus administration. Ex vivo plasma endotoxin-induced tumour necrosis factor activity was significantly decreased at 1.5 and 3 h of infusion. These results indicate that infusion of pentoxifylline will increase 6-keto-prostaglandin F1 alpha and significantly suppress endotoxin-induced tumou...Continue Reading

Citations

Jun 24, 2005·Australian Veterinary Journal·B W Sykes, M O Furr
Aug 17, 2010·Journal of Veterinary Internal Medicine·B KornreichT Divers
Nov 19, 2011·The Veterinary Journal·John D Mitchell, Jonathan Elliott
Oct 12, 2011·The Veterinary Journal·N KabbeshM Y Mallem
Sep 21, 2013·European Journal of Pharmacology·Nasr KabbeshMohamed Yassine Mallem
Mar 12, 2011·The Veterinary Clinics of North America. Equine Practice·Rosa J Barsnick, Ramiro E Toribio
Sep 20, 2011·Innate Immunity·José P Oliveira-FilhoAlexandre S Borges
Sep 27, 2018·Equine Veterinary Journal·E M MartinJ L Davis
Jul 13, 2011·Journal of Veterinary Internal Medicine·C J AlcottW Hsu
Oct 17, 2017·Frontiers in Veterinary Science·Emily Medlin MartinSamuel L Jones
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Barbara L Dallap Schaer, Kira Epstein
Jul 24, 2010·Journal of Veterinary Internal Medicine·J R PeiróC A A Valadão
Jul 28, 2016·Journal of Veterinary Pharmacology and Therapeutics·A H Werners
Dec 3, 2016·American Journal of Veterinary Research·Daniela HernandezTracy Stokol

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