PMID: 3383991Jan 1, 1988Paper

The effects of perhexiline maleate on low density lipoprotein processing and cholesterol metabolism in cultured human fibroblasts

European Journal of Clinical Pharmacology
C CandideJ Polonovski

Abstract

The effects of perhexiline maleate (PM, Pexid) on low density lipoprotein (LDL) processing and cholesterol metabolism were investigated after a 24 h pretreatment with the drug. Perhexiline maleate increased LDL uptake in the range 10(-6) to 10(-5) M (180% of control for 10(-5) M), whereas LDL binding and degradation were not affected. Sterol synthesis from sodium acetate was enhanced by perhexiline maleate (X 2.2 for 10(-5) M), while cholesterol esterification with oleic acid was decreased (40% of control for 10(-5) M). These effects of perhexiline on cholesterol metabolism are specific, since the synthesis of triacylglycerols from sodium acetate is not affected and since the incorporation of oleic acid into triacylglycerols is much less impaired. The decreased cholesterol esterification is accompanied by a reduction of acylcoenzyme A-cholesterol-O-acyltransferase (ACAT) activity measured in vitro on cell extracts.

References

Feb 26, 1977·Lancet·A LageronV G Lévy
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Aug 1, 1987·Journal of Biochemical and Biophysical Methods·C MazièreJ Polonovski
Jan 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·O SteinY Stein
Jul 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M S BrownJ L Goldstein
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
Jan 1, 1981·European Journal of Clinical Pharmacology·A LageronM Gautier
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K L GaveyT J Scallen
Jun 1, 1983·Journal of the American College of Cardiology·J L RouleauR J Havel
Jul 16, 1982·Biochemical and Biophysical Research Communications·S RanganathanR J Jackson
Nov 1, 1981·The Journal of Clinical Investigation·P D Henry, K I Bentley
Sep 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·S AlbouzN Baumann
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

❮ Previous
Next ❯

Citations

Jan 1, 1991·Free Radical Research Communications·C BreugnotJ C Mazière
Jan 1, 1995·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·T HumkeH Siegrist
Feb 1, 1991·Clinical Cardiology·J T Gwynne
May 2, 1990·Biochimica Et Biophysica Acta·B Chappey-GilletJ C Mazière

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.