PMID: 6407847Jan 1, 1983Paper

The effects of peritoneal dialysis on the single dose and steady state pharmacokinetics of valproic acid in a uremic epileptic child

European Journal of Clinical Pharmacology
J OrrW J Godolphin

Abstract

The pharmacokinetics of valproic acid (VPA) have been studied during peritoneal dialysis in a uremic male epileptic child following a single 500 mg dose and after multiple doses over 5 months (700 mg daily) of valproic acid as the syrup. Serum level decline was biphasic in both instances with a terminal half-life of 27.2 after the single dose and 10.2 h at steady-state. Total serum clearance was 0.0236 l/h/kg after the single dose and increased to 0.0408 l/h/kg after 5 months. Free (intrinsic) serum clearances were 0.1489 and 0.1518 l/h/kg and serum free fractions were 0.224 and 0.272 respectively for the single dose and steady-state studies. Peritoneal dialysis for periods of 12 or 24 h removed an average of 4.5% of the VPA dose.

References

Aug 1, 1979·British Journal of Clinical Pharmacology·A Monks, A Richens
Feb 28, 1975·European Journal of Clinical Pharmacology·F SchobbenF J Gabreëls
Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand
Jan 1, 1980·Clinical Pharmacokinetics·R Gugler, G E von Unruh
May 1, 1980·Neurology·J BruniB J Wilder
Jan 1, 1980·European Journal of Clinical Pharmacology·G J SchapelP E Stanley
Jan 1, 1980·Clinical Pharmacology and Therapeutics·D Brewster, N C Muir
Aug 1, 1976·British Journal of Clinical Pharmacology·S AhmadA Richens

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Citations

May 20, 1982·Brain Research·E J HammondB J Wilder
Aug 15, 2000·Epilepsy Research·E PeruccaT Tomson
May 8, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marc GhannoumUNKNOWN EXTRIP Workgroup
Nov 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W M BennettI Singer

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