Apr 24, 2020

Bidirectional pharmacological perturbations of the noradrenergic system differentially affect tactile detection

BioRxiv : the Preprint Server for Biology
J. McBurney-LinHongdian Yang

Abstract

The brain neuromodulatory systems heavily influence behavioral and cognitive processes. Previous work has shown that norepinephrine (NE), a classic neuromodulator mainly derived from the locus coeruleus (LC), enhances neuronal responses to sensory stimuli. However, the role of the LC-NE system in modulating perceptual task performance is not well understood. In addition, systemic perturbation of NE signaling has often been proposed to specifically target the LC in functional studies, yet the assumption that localized (specific) and systemic (nonspecific) perturbations of LC-NE have the same behavioral impact remains largely untested. In this study, we trained mice to perform a head-fixed, quantitative tactile detection task, and administered an 2 adrenergic receptor agonist or antagonist to pharmacologically down- or up-regulate LC-NE activity, respectively. We addressed the outstanding question of how bidirectional perturbations of LC-NE activity affect tactile detection, and tested whether localized and systemic drug treatments exert the same behavioral effects. We found that both localized and systemic suppression of LC-NE impaired tactile detection by reducing motivation. Surprisingly, while locally activating LC-NE enabled...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Interleukins
Study
CYP2C19 gene
UGT1A1 protein, human
Enzymes, antithrombotic
Environment
Cytochrome P-450 CYP2D6
UGT1A1 gene
Evaluation
Objective (Goal)

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

American Journal of Pharmaceutical Education
Kristin Wiisanen WeitzelJulie A Johnson
American Journal of Pharmaceutical Education
Erini S Serag-BolosRadha V Patel
American Journal of Pharmaceutical Education
Mikel Marku, Bryan C McCarthy
© 2020 Meta ULC. All rights reserved