The effects of PGE2 and PGF2 alpha on rhythmic contractions of sphincter of Oddi

General Pharmacology
F GöçerM Tuncer


1. Spontaneous rhythmic activity observed in some of the guinea-pig sphincter of Oddi preparations was completely abolished by PGE2 (10(-8) M) but not altered by PGF2 alpha (10(-6) M). 2. Indomethacin (10(-5) M), a cyclooxygenase inhibitor, elicited long-lasting rhythmic contractions in 50% of the preparations tested, which did not show any spontaneous activity. PGE2 (10(-8) M) completely inhibited, however PGF2 alpha (10(-8)-10(-6) M) did not change the rhythmic contractions induced by indomethacin. 3. Both initial phasic contraction and the frequency and amplitude of peristaltic waves induced by ACh (10(-3) M) were increased by indomethacin (10(-5) M), decreased by PGE2 (10(-7) M) and not altered by PGF2 alpha (10(-7) M).


Aug 31, 1979·World Journal of Surgery·D L Kaminski, D L Nahrwold
Jan 11, 1975·European Journal of Pharmacology·J Nakano, R B McCloy
May 1, 1990·Pharmacology, Biochemistry, and Behavior·T J PotterC Van Hartesveldt
Nov 1, 1968·British Journal of Pharmacology·A BennettG B Scholes
Nov 1, 1968·British Journal of Pharmacology·A BennettG B Scholes
Jan 1, 1983·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·E Martinez, J C Sarles

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