PMID: 8602173Mar 26, 1996Paper

The effects of pH and bile salts on the binding of MeIQx to wheat bran fibre

Mutation Research
P Ryden, J A Robertson

Abstract

The effects of pH and of the bile salts, sodium cholate, chenodeoxycholate, taurocholate, deoxycholate and glycodeoxycholate on the adsorption of the heterocyclic aromatic amine mutagen and carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) onto wheat bran cell wall material have been examined. The highest binding affinity of MeIQx for bran was at pH 5.5. Binding affinity declined more rapidly with pH > 5.5 than with pH < 5.5. Bile salts in solution did not appreciably affect the binding of MeIQx to bran, but where the bile salts formed a suspension then the adsorption was reduced. Where precipitation of bile salts occurred then the free concentration of MeIQx was also reduced, indicating that MeIQx binding/immobilization could be enhanced through interaction with bile salts.

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Citations

Oct 20, 1999·Mutation Research·G Santana-Rios, R H Dashwood
Jun 9, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z YuR H Dashwood
Mar 3, 2007·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Daitaro Kurosaka
Mar 6, 2008·Molecular Nutrition & Food Research·Reinhard StidlSiegfried Knasmüller
Aug 17, 2006·Journal of Agricultural and Food Chemistry·B Stephen InbarajB H Chen

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