PMID: 36597May 15, 1979

The effects of pH on Ca2+-activated force in frog skeletal muscle fibers

Pflügers Archiv : European journal of physiology
S P Robertson, W Glenn L Kerrick


Ca2+-activated isometric force was recorded is skinned (sarcolemma mechanically removed) segments of frog skeletal muscle fibers immersed in bathing solution of different pH (5.0--10.5) and Ca2+ concentrations. Force in maximally activated fibers was near zero at pH 5.5, increased as pH increased to 7.5, remained relatively constant until pH 9.0 and then rapidly declined to zero by pH 10.5. The Ca2+ concentration at which 50% of maximum force was developed decreased 25-fold as pH increased from 5.5--7.5. The data also indicate that, while the fibers remains viable with acidosis, they deteriorate rapidly with alkalosis. These observations may be relevant clinically, since they parallel known effects of acidosis on cardiac contractility. The possible sites of action of H+ on the Ca2+-activated force generating mechanisms are discussed.


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Jan 1, 1983·European Journal of Applied Physiology and Occupational Physiology·P A Tesch, J E Wright
Jun 1, 1983·Pflügers Archiv : European journal of physiology·G J StienenJ C Rüegg
Sep 1, 1985·Pflügers Archiv : European journal of physiology·G J StienenB W Treijtel
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·E B CollianderP A Tesch
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·H KanehisaT Fukunaga
Jan 1, 1981·Acta Physiologica Scandinavica·J T Viitasalo, P V Komi
Sep 1, 1983·Acta Physiologica Scandinavica·P A TeschJ T Viitasalo
Mar 1, 1990·Acta Physiologica Scandinavica·P A TeschR T Harris
Nov 1, 1994·Acta Physiologica Scandinavica·G S LynchD A Williams
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Mar 25, 2004·The Japanese Journal of Physiology·Shin-ichi MiyakeTeizo Tsuchiya
Apr 4, 2000·Physiological Reviews·A M GordonM Regnier
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Aug 1, 1976·The Journal of General Physiology·V W MacDonald, F F Jöbsis
Dec 1, 1977·Circulation Research·C SteenbergenJ R Williamson
Oct 1, 1975·The Journal of General Physiology·S K Donaldson, W Glenn L Kerrick
Jul 12, 1972·Biochimica Et Biophysica Acta·W Glenn L Kerrick, S K Donaldson
Dec 30, 1972·Journal of Molecular Biology·I Matsubara, G F Elliott
Apr 1, 1974·The Journal of General Physiology·M D ThamesR J Podolsky
Feb 1, 1969·The Journal of Physiology·D C Hellam, R J Podolsky
Jun 1, 1957·Biochimica Et Biophysica Acta·F N BRIGGS, H PORTZEHL

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