The effects of phenytoin dosage on the induction of alpha 1-acid glycoprotein and antipyrine clearance in the dog

European Journal of Drug Metabolism and Pharmacokinetics
F P Abramson, M P Lutz

Abstract

Doses of phenytoin from 90 to 800 mg/d were used to study induction of hepatic cytochrome P-450 and plasma alpha 1-acid glycoprotein in dogs. The antipyrine clearance was increased by 80%, which is equivalent to an increase in cytochrome P-450 of 140%, and the plasma glycoprotein concentration rose 200% at the highest dose of phenytoin used. Plasma concentrations of phenytoin were measured at each dose level to provide a definitive value for the amount of inducer present. These data were used to assess the concentration-response relationship for phenytoin inducing either cytochrome P-450 or the glycoprotein. A simple relationship between concentration and effect was not observed, suggesting a complex mechanism of induction.

References

Dec 1, 1979·Computer Programs in Biomedicine·G D Knott
Mar 1, 1986·Journal of Pharmaceutical Sciences·F P Abramson
Jul 1, 1973·Clinical Pharmacology and Therapeutics·A BreckenridgeD S Davies
Sep 1, 1973·Clinical Pharmacology and Therapeutics·B J WilderR E Ramsay
Jul 26, 1974·European Journal of Clinical Pharmacology·F PetruchG Steinhilber
Oct 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·N TavoloniP D Berk
Jan 1, 1982·Human Genetics·C RaffouxF Streiff
Oct 1, 1980·Clinical Pharmacology and Therapeutics·D JungD Perrier

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Citations

Dec 1, 1991·Inflammation·F E LevyJ P Giroud
Apr 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·F P Abramson
Aug 5, 2000·Journal of Pharmacological and Toxicological Methods·M J Garrido, I F Trocóniz
Nov 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·S A Brown
Aug 23, 2003·European Journal of Anaesthesiology·P Hans, V Bonhomme
Jul 23, 2005·Journal of Neurosurgical Anesthesiology·Paul B AuduDavid Andrews
Feb 5, 2002·Clinical Pharmacokinetics·Jorn LotschGerd Geisslinger
Mar 10, 1990·BMJ : British Medical Journal·P O'ConnorJ Shepherd

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