PMID: 8596712Feb 1, 1996Paper

The effects of phosphocreatine introduced simultaneously into many cardiac cells

Pflügers Archiv : European journal of physiology
W Tuganowski

Abstract

The aim of the present study was to ascertain whether or not phosphocreatine (PC) could produce electrophysiological and inotropic effects in isolated rabbit cardiac preparations. Exogenous PC (50 mmol/l) was introduced into many cells simultaneously by the "cut-end" and "saponinated-end" methods. PC that entered the cells (opened by cutting or chemical disruption of the sarcolemma) in the loading region, passed through the preparation intercellularly and evoked the following effects in the test region. PC enhanced the spontaneous rate and probably shifted the pacemaker in sinus node strips. On the other hand, PC elevated the action potential amplitude and duration and increased the isometric tension in atrial and ventricular strips. Furthermore, PC applied into ventricular cells partially prevented the effects of hypoxia. These findings suggest that PC may act in cardiac muscle as an intercellular energy carrier. The effects of PC introduced intracellularly resembled these evoked by O-benzyl-phosphocreatine--a permanent synthetic phosphagen--applied via superfusion.

References

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Jan 1, 1988·Ion Channels·A Noma, T Shibasaki
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Mar 1, 1973·The Journal of Physiology·T F McDonald, D P MacLeod
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Oct 1, 1984·Journal of Muscle Research and Cell Motility·M R Iyengar
Sep 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·W Tuganowski

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Citations

Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Sabatini
May 12, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P P Dzeja, A Terzic

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