The effects of photodynamic and low-level laser therapy for treatment of oral lichen planus-A systematic review and meta-analysis

Photodiagnosis and Photodynamic Therapy
Hasan Hoseinpour JajarmMaryam Emadzadeh

Abstract

Oral lichen planus (OLP) is a chronic immune-mediated disorder that inflicts oral mucosa in 0.5-2% of the population. Surgery, photodynamic therapy, laser therapy and most commonly pharmacological therapy (like corticosteroids) has been used for treating OLP. New phototherapy approaches have been shown to have positive effects on treating some oral lesions and the aim of our study was to assess the effects of different phototherapy treatments on OLP. We conducted a comprehensive electronic search using the determined search strategy in MEDLINE, EMBASE and CENTRAL electronic databases. A hand search of the reference list of the relevant studies and related systematic reviews was also performed. For low-level laser therapy, before and after studies showed a significant difference in pain (MD = -4.39, CI = 95% -4.83, -3.96) and sign score (MD = -1.86, CI = 95% -2.53, -1.19) after treatment. The comparison between corticosteroid therapy and LLLT also showed a significant difference in their effects for severity (MD = 0.57, CI = 95% 0.04, 1.09), but no differences in sign (MD = 0.21, CI = 95% -0.83, 1.24)and pain (MD = -0.10, CI = 95% -0.57,0.38) score was found between these two methods. Before and after studies of photodynamic the...Continue Reading

Citations

Oct 8, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Elisabetta MerigoCarlo Fornaini
Sep 29, 2020·International Journal of Nanomedicine·Yun-Jing HouHong-Xue Meng
May 6, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Massimo PetruzziFelice Roberto Grassi
Feb 1, 2019·Head and Neck Pathology·Sarah G FitzpatrickAshley N Clark
Dec 15, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Antonio RomanoAlberta Lucchese
Feb 20, 2021·Photobiomodulation, Photomedicine, and Laser Surgery·Bingjie WangLuyi Chai
Jun 3, 2021·Pharmaceutics·Marcin OlekAleksandra Kawczyk-Krupka
Jan 14, 2022·Clinical Oral Investigations·Milena Moraes de CarvalhoMarina Lara de Carli

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