The effects of piperoxan on uptake of noradrenaline and overflow of transmitter in the isolated blood perfused spleen of the cat

British Journal of Pharmacology
A G Blakeley, R J Summers


1 The competitive alpha-adrenoceptor blocking agent, piperoxan, in concentrations up to 2 x 10(-4) M, produced large dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimulation at 10 hertz. 2 At concentrations greater than 2 x 10(-4) M, piperoxan produced a rise in perfusion pressure, a contraction of the splenic capsule, and a marked dose-dependent decrease in transmitter overflow. 3 Phenoxybenzamine (10(-4) M) and desmethylimipramine (3 x 10(-5) M) produced further increases in transmitter overflow when added after piperoxan. 4 Piperoxan (5.8 to 6.6 x 10(-6) M) had no effect on the recovery of 3H in the venous blood following the close arterial infusion or injection of (3H)-(--)-noradrenaline, indicating that the drug does not inhibit uptake of the amine. 5 Piperoxan produced dose-dependent inhibition of responses of the splenic vasculature to close arterial injection of 1 microgram of (--)-noradrenaline but was much less effective at inhibiting responses to nerve stimulation. At 2 x 10(-6) M piperoxan produced a considerable reduction of the response to injected noradrenaline but potentiated the response to nerve stimulation. 6 In isolated strips of cat sple...Continue Reading


Feb 1, 1976·British Journal of Pharmacology·A Jurkiewicz, N H Jurkiewicz
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Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·T EndoH D Taube
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Feb 1, 1972·The Journal of Pharmacy and Pharmacology·J HäggendalB Ljung
Feb 10, 1967·Annals of the New York Academy of Sciences·E J Ariëns
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Jan 1, 1982·Clinical and Experimental Pharmacology & Physiology·G A McPherson, R J Summers
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