The effects of platelet-derived growth factor-BB and insulin-like growth factor-1 on epithelial dysplasia

Journal of Periodontology
S D ShihA M Iacopino

Abstract

Growth factors are multi-functional and multi-targeted proteins which play a significant role in wound healing. Platelet-derived growth factor B-chain homodimer (PDGF-BB) and insulin-like growth factor-1 (IGF-1) have demonstrated efficacy for periodontal regeneration in animal models. Although primarily associated with wound healing, PDGF-BB and IGF-1 also facilitate growth of a number of malignant neoplasms. Of particular concern to periodontists is epithelial dysplasia, a necessary precursor to squamous cell carcinoma, the most common oral malignancy. Certain risk factors for oral cancer, such as tobacco, age, and alcohol, are also associated with an increased incidence of periodontal disease. The effects of the combination of PDGF-BB and IGF-1 on epithelial dysplasia have not previously been reported. The purpose of this study was to examine the effects of the combination of PDGF-BB and IGF-1 on epithelial dysplasia induced in the buccal cheek pouch of the Syrian golden hamster. A total of 66 hamsters received 18 applications of 0.5% dimethylbenzanthracene (DMBA), a topical carcinogen, over a 6-week period for the induction of dysplasia. The hamsters were subsequently divided into a baseline and 3 experimental groups (growth...Continue Reading

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Oct 29, 2009·Tissue Engineering. Part B, Reviews·Fa-Ming Chen, Yan Jin
Mar 19, 2005·Head & Neck·David M Jakubowicz, Richard V Smith
Sep 6, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Christof RöösliAlex M Huber
Jul 3, 2016·Molecular and Cellular Biochemistry·Alexandra Iulia IrimieIoana Berindan-Neagoe

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