The Effects of Portulaca oleracea on Hypoxia-Induced Pulmonary Edema in Mice

High Altitude Medicine & Biology
Tan YueLi Min

Abstract

Portulaca oleracea L. (PO) is known as "a vegetable for long life" due to its antioxidant, anti-inflammatory, and other pharmacological activities. However, the protective activity of the ethanol extract of PO (EEPO) against hypoxia-induced pulmonary edema has not been fully investigated. In this study, we exposed mice to a simulated altitude of 7000 meters for 0, 3, 6, 9, and 12 h to observe changes in the water content and transvascular leakage of the mouse lung. It was found that transvascular leakage increased to the maximum in the mouse lung after 6 h exposure to hypobaric hypoxia. Prophylactic administration of EEPO before hypoxic exposure markedly reduced the transvascular leakage and oxidative stress, and inhibited the upregulation of NF-kB in the mouse lung, as compared with the control group. In addition, EEPO significantly reduced the levels of proinflammatory cytokines and cell adhesion molecules in the lungs of mice, as compared with the hypoxia group. Our results show that EEPO can reduce initial transvascular leakage and pulmonary edema under hypobaric hypoxia conditions.

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Citations

Aug 11, 2016·Anais Da Academia Brasileira De Ciências·Waleska B MartinsMargarete Z Gomes
Jul 23, 2019·High Altitude Medicine & Biology·Ching-Lung KoMin-Hui Li
Aug 29, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shih-Hung TsaiShing-Jong Lin
Aug 5, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Biruk KassaBrian B Graham

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Methods Mentioned

BETA
bronchoalveolar lavage
lavage
enzyme-linked immunosorbent assay
electrophoresis
MDA
ELISA

Software Mentioned

LabWorks

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