The effects of poststroke captopril and losartan treatment on cerebral blood flow autoregulation in SHRsp with hemorrhagic stroke.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
John S Smeda, Noriko Daneshtalab

Abstract

The ability of captopril and losartan treatment to restore cerebral blood flow (CBF) autoregulation after intracerebral hemorrhagic stroke (HS) was assessed in Kyoto-Wistar stroke-prone hypertensive rats (SHRsp). Laser Doppler techniques assessed CBF autoregulation in the middle cerebral artery (MCA) perfusion domain and a pressure myograph was used to measure pressure-dependent constriction (PDC) in isolated MCAs before and after stroke and after 13, 33, and 63 days of poststroke captopril or losartan treatment. The treatments did not lower blood pressure (BP) and equally suppressed plasma aldosterone after HS. The HS development was associated with the loss of CBF autoregulation, high CBF, increased CBF conductance to elevations in BP, and the loss of PDC in the MCAs. Both treatments restored these functions to prestroke levels within 13 days. The PDC and CBF autoregulation subsequently deteriorated after 63 days of captopril treatment while being maintained at prestroke levels over all durations of losartan treatment. The SHRsp subjected to 35 days of poststroke losartan treatment exhibited less blood-brain barrier (BBB) disruption and brain herniation than captopril-treated SHRsp. The superior ability of losartan to restore...Continue Reading

References

Apr 1, 1991·American Journal of Hypertension·M J CamargoJ H Laragh
Apr 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·K UdakaH Z Movat
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·G L BaumbachD D Heistad
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·J P BroderickG Huster
Apr 16, 1998·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J D Port, N J Beauchamp
Nov 5, 1999·Stroke; a Journal of Cerebral Circulation·M R Del BigioJ Peeling
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·J S Smeda, S King
Feb 24, 2001·American Journal of Hypertension·E L BlezerJ A Joles
Mar 20, 2001·The Journal of Clinical Investigation·C GuoM Rabinovitch
Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·M Miyazaki, S Takai
May 14, 2003·Brain Research·Luigi SironiLuciana Mussoni
Mar 18, 2004·Current Medical Research and Opinion·Michael Alderman, Kala J V Aiyer
Aug 11, 2004·The Journal of Pharmacology and Experimental Therapeutics·Luigi SironiElena Tremoli
Jan 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun LiThomas Unger
May 26, 2005·Stroke; a Journal of Cerebral Circulation·Shinichiro IidaDonald D Heistad
May 9, 2006·Journal of Neurology·José M Ferro
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Jin-Moo LeeWeili Lin
Nov 27, 2007·Expert Opinion on Pharmacotherapy·N AsdaghiK Butcher
Feb 26, 2008·Trends in Endocrinology and Metabolism : TEM·Robert M Carey, Shetal H Padia
Jul 7, 2009·Current Opinion in Critical Care·Craig S Anderson
Sep 3, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshinobu WakisakaDonald D Heistad

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Citations

Nov 1, 2012·Experimental & Translational Stroke Medicine·Quynh N DinhSophocles Chrissobolis
Oct 11, 2012·Current Cardiovascular Risk Reports·Vera Novak
May 9, 2012·Current Atherosclerosis Reports·Qingliang T Wang, Stanley Tuhrim
Oct 28, 2014·Expert Review of Neurotherapeutics·Alon FriedmanDaniela Kaufer
May 15, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Serhat TokgozMehmet Yucel
Jan 2, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Khaled S Abd-ElrahmanWilliam C Cole
Mar 9, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Amynah A PradhanSimon Akerman
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Oct 5, 2018·Therapeutic Advances in Neurological Disorders·Chi-Hung LiuTsong-Hai Lee
Feb 8, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·P R KamchatnovL I Pyshkina
Sep 15, 2020·Frontiers in Neuroscience·Asuka Matsuzaki TadaIkuo Tooyama
Sep 22, 2020·Pharmacology & Therapeutics·Jason D Vadhan, Robert C Speth

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