The effects of pregnancy and parturition on the levels of substance P-like immunoreactivity in different areas of the hypothalamus

General Pharmacology
S AmiraK M Rayfield

Abstract

1. The concentrations of substance P-like immunoreactivity (SPLI) have been measured in the rostral and caudal areas of the hypothalamus of male rats and of virgin, pregnant and puerperal female rats. 2. The rostral:caudal ratio of SPLI is similar in males and virgin females, but diminishes in pregnancy and decreases further during the puerperium. In the pre-optic area, the SPLI concentration fell significantly during parturition, from 241.8 to 177.2 pmols/g wet weight (P < 0.05), and in the medio-basal hypothalamus, the concentration rose during pregnancy and parturition, from 87.4 to 145.5 pmols/g wet weight (P < 0.001). 3. The results are discussed in relation to the endocrine and nociceptive aspects of pregnancy and parturition.

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