PMID: 8959041Oct 31, 1996Paper

The effects of prenatal cocaine exposure on dopaminergic challenge and receptor binding in Wistar rats

Annals of the New York Academy of Sciences
K A BensonM C Wilson

Abstract

The behavioral teratogenic effects of prenatal cocaine administration in Wistar rats were assessed in dams treated throughout gestation via oral gavage with either 0 or 80 mg/kg of cocaine. A pair-fed (PF) cohort group for the 80-mg/kg dose was used to control for an anorexic effect of cocaine. Alterations in the dopaminergic system at maturity were evaluated using pharmacological challenges with amphetamine and cocaine and by measuring D1 and D2 receptor binding in the nucleus accumbens and caudate nucleus. No significant difference among the offspring of the treatment groups was found in amphetamine-induced locomotion. A cocaine-based conditioned taste aversion was established in all offspring, but no significant effect of prenatal cocaine treatment was seen. Dopamine receptor binding was not significantly influenced by prenatal treatment, although a decreased D1 binding in the caudate nucleus of the prenatal cocaine rats approached significance.

References

Jun 1, 1978·Pharmacology, Biochemistry, and Behavior·A J GoudieE W Thornton
Dec 15, 1990·Brain Research. Developmental Brain Research·D L Dow-EdwardsT A Fico
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·S K SobrianL M Turner
Sep 1, 1993·Neurotoxicology and Teratology·P M KunkoS E Robinson

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Citations

Jul 17, 2001·Brain Research. Developmental Brain Research·D L Dow-EdwardsL M Gerkin
Dec 7, 2000·Neurotoxicology and Teratology·S J GlattD Jackson
Feb 14, 2006·Neurotoxicology and Teratology·Annelyn Torres-Reveron, Diana L Dow-Edwards
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Melissa M MartinGregg D Stanwood

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