Abstract
The incidence of Down syndrome (DS) at conception is highly dependent on the maternal age distribution and age-specific pregnancy rates. The live birth prevalence of DS reflects these factors and fetal deaths. This study examined DS live birth prevalence from 1983 to 1992 in New York State and analysed the effects of demographic changes and prenatal diagnosis use on the observed live birth prevalence. Expected DS live birth prevalence without prenatal diagnosis was calculated and compared with observed. Data were obtained from birth defects registries, vital records, and population data maintained by the New York State Department of Health. Over time, DS live birth prevalence was stable at about 10.4 per 10,000 live births. The percentage and number of women in the population above age 30 increased, as did birth rates among these women. Birth rates among younger women decreased. The proportion of DS babies born to women aged 35 and over increased from 27.1 to 34.1 per cent. Use of prenatal diagnosis by this age group ranged from 39.6 to 43.2 per cent, and increased steadily from 1.8 to 4.3 per cent among women under 35. Detection of DS fetuses increased from 82 in 1985 to 233 in 1992. Without prenatal diagnosis, DS live birth p...Continue Reading
References
Nov 9, 1978·The New England Journal of Medicine·E B Hook
Jul 1, 1989·Paediatric and Perinatal Epidemiology·D H StoneJ Womersley
Jan 1, 1989·Hereditas·B Källén, L B Knudsen
Mar 1, 1986·The Journal of Hospital Infection·M W Casewell
Apr 1, 1988·American Journal of Medical Genetics·P A Baird, A D Sadovnick
Jun 1, 1982·American Journal of Epidemiology·C A Huether, G R Gummere
May 1, 1983·Annals of Human Genetics·M MikkelsenJ Nielsen
Oct 1, 1983·American Journal of Public Health·C A Huether
Oct 1, 1983·British Medical Bulletin·M A Ferguson-Smith
Jan 1, 1981·Human Genetics·C A BarbosaH Krieger
Jul 1, 1995·Paediatric and Perinatal Epidemiology·P M LopezH Gilmour
Dec 1, 1993·Teratology·L M James
Sep 1, 1993·Human Genetics·M C CornelL P ten Kate
Apr 15, 1993·American Journal of Epidemiology·E KrivcheniaS Guckenberger
Mar 1, 1993·Prenatal Diagnosis·G J KnightH Schneider
Citations
Jan 22, 2000·Proceedings. Biological Sciences·J E Lycett, R I Dunbar
Jan 18, 2006·BMC Medical Genetics·Suttur S Malini, Nallur B Ramachandra
Sep 2, 2006·BMC Health Services Research·Evelyne E MuggliJane L Halliday
Apr 13, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·T RousseauP Sagot
Apr 30, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gert de GraafBrian G Skotko
Jul 12, 2005·Nursing Ethics·P Alderson
Mar 12, 1999·Prenatal Diagnosis·J GekasF Thepot
Sep 12, 2002·Prenatal Diagnosis·Michael MutterAlbert Schinzel
Feb 19, 1998·Prenatal Diagnosis·C L Olsen, P K Cross
Apr 17, 2008·American Journal of Medical Genetics. Part a·Ariko TakeuchiKousaku Ohno
Nov 26, 2009·Journal of Autism and Developmental Disorders·Gemma M GriffithChristopher Hill
Jul 1, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Guido CocchiGöran Annerén
Aug 26, 1998·Prenatal Diagnosis·B C SheuF J Hsieh
Oct 22, 1996·Proceedings. Biological Sciences·J G VernonL R Noble
May 25, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D A Coleman
Oct 30, 2015·Italian Journal of Pediatrics·Tatjana GliveticMaida Seferovic Saric
Mar 23, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·T M CarusoL B Holmes