PMID: 7540733Mar 1, 1995Paper

The effects of pretreatment with tachykinin antagonists and galanin on the development of spinal cord hyperexcitability following sciatic nerve section in the rat

Neuropeptides
L Luo, Z Wiesenfeld-Hallin

Abstract

The effects of acute section of the sciatic nerve on the excitability of the flexor reflex was examined in decerebrate, spinalized, unanaesthetized rats. In control experiments without drugs, the excitability of the flexor reflex was dramatically increased in two phases following axotomy. An early intense, brief reflex hyperexcitability was followed by a less intense, prolonged period of facilitation. The selective NK1 tachykinin receptor antagonist CP-96,345 injected intrathecally at lower (1.2-2.4 nmol) and higher (12 nmol) doses blocked both components of spinal sensitization. The selective NK2 tachykinin receptor antagonist Men 10376 at a dose of 2.4 nmol also reduced both response components, as did the same dose of the inhibitory neuropeptide galanin. Thus, antagonists of excitatory neuropeptides released during and after nerve section, such as substance P and neurokinin A, can block the spinal response to peripheral nerve injury. Furthermore, the inhibitory neuropeptide galanin also reduced spinal cord sensitization.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z Wiesenfeld-HallinT Bartfai
Sep 4, 1992·European Journal of Pharmacology·A W SchmidtJ Heym
Dec 1, 1974·Experimental Neurology·P D WallA I Basbaum
Apr 1, 1993·Acta Physiologica Scandinavica·Z Wiesenfeld-HallinT Hökfelt
Jan 4, 1994·European Journal of Pharmacology·Z Wiesenfeld-HallinC A Maggi

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Citations

Feb 13, 1999·Progress in Neurobiology·M J Millan
Aug 25, 2000·European Journal of Pain : EJP·D G SnijdelaarB J Crul
Jun 13, 2001·Spinal Cord·P J Siddall, J D Loeser
Apr 12, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Arthur de Sá Ferreira

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