The Effects of Probiotic Honey Consumption on Metabolic Status in Patients with Diabetic Nephropathy: a Randomized, Double-Blind, Controlled Trial

Probiotics and Antimicrobial Proteins
Navid Mazruei AraniZatollah Asemi

Abstract

To the best of our knowledge, this study is the first evaluating the effects of probiotic honey intake on glycemic control, lipid profiles, biomarkers of inflammation, and oxidative stress in patients with diabetic nephropathy (DN). This investigation was conducted to evaluate the effects of probiotic honey intake on metabolic status in patients with DN. This randomized, double-blind, controlled clinical trial was performed among 60 patients with DN. Patients were randomly allocated into two groups to receive either 25 g/day probiotic honey containing a viable and heat-resistant probiotic Bacillus coagulans T11 (IBRC-M10791) (108 CFU/g) or 25 g/day control honey (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and 12 weeks after supplementation to quantify glycemic status, lipid concentrations, biomarkers of inflammation, and oxidative stress. After 12 weeks of intervention, patients who received probiotic honey compared with the control honey had significantly decreased serum insulin levels (- 1.2 ± 1.8 vs. - 0.1 ± 1.3 μIU/mL, P = 0.004) and homeostasis model of assessment-estimated insulin resistance (- 0.5 ± 0.6 vs. 0.003 ± 0.4, P = 0.002) and significantly improved quantitative insulin sensitiv...Continue Reading

References

Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Mar 3, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J R EndresA G Schauss
Jan 27, 2010·The British Journal of Nutrition·Haleh Sadrzadeh-YeganehMaryam Chamary
Dec 28, 2010·Clinical Biochemistry·Etiane TatschRafael Noal Moresco
Jun 18, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Eduardo EsteveJose-Manuel Fernández-Real
Aug 18, 2012·Journal of Agricultural and Food Chemistry·Prithy Rupa, Yoshinori Mine
Sep 21, 2012·Kidney International·Nosratola D VaziriGary L Andersen
Jul 10, 2013·The Journal of Biological Chemistry·Hariom YadavSushil G Rane
Aug 1, 2014·Hormones : International Journal of Endocrinology and Metabolism·Mohsen Taghizadeh, Zatolla Asemi
Sep 6, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alice SabatinoEnrico Fiaccadori
Sep 27, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine R TuttleMark E Molitch
May 8, 2015·The Journal of Nutrition·Edna P NyangaleGlenn R Gibson
May 21, 2015·Current Diabetes Reports·Mark Henry Joven, Robert J Anderson
Jul 7, 2015·Journal of Diabetes and Its Complications·Mercedes Molina MendezJose T Real
Jan 1, 2014·International Journal of Chronic Diseases·Dipika BansalAnil Bhansali
Nov 11, 2015·Nature Reviews. Nephrology·Merlin C ThomasPaul Zimmet
Dec 9, 2016·Kidney International·Alireza SoleimaniZatollah Asemi
Jun 24, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kecheng YaoXiulan Zou
Aug 26, 2017·Journal of Thoracic Disease·Srikanth Yandrapalli, Wilbert S Aronow
Jun 15, 2018·Foods·Gözde Konuray, Zerrin Erginkaya
Jul 20, 2018·International Journal of Molecular Sciences·Tao WuYongqing Hou

❮ Previous
Next ❯

Citations

Jul 3, 2019·Antibiotics·Azadeh Tavakoli, Judith Louise Flanagan
Nov 7, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Edris ArdeshirlarijaniReza Baradar Jalili
Mar 6, 2021·Journal of Clinical Laboratory Analysis·Hongyang JiangQing Wang
Apr 4, 2021·International Journal of Molecular Sciences·Gratiela Gradisteanu PircalabioruOctavian Savu
Jul 6, 2021·Journal of Diabetes and Metabolic Disorders·Amir Reza MoravejolahkamiMarjan Mansourian
Mar 4, 2020·Current Clinical Pharmacology·Eugenia VlachouGeorge Dimitriadis
Jul 6, 2021·The British Journal of Nutrition·Zohreh GholamiNasrin Nasimi
Nov 14, 2020·Clinical Nutrition ESPEN·Yossef Hassan AbdelQadirAnas Zakarya Nourelden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.