The effects of probiotics on treatment of Helicobacter pylori eradication in children

Saudi Medical Journal
Mustafa AkcamNermin Karahan

Abstract

To investigate the eradication rates and side effects of probiotics added in standard triple therapy for the treatment of Helicobacter pylori (H. pylori). A prospective open study was performed in the outpatient clinics of the Department of Pediatric Gastroenterology, School of Medicine, Suleyman Demirel University, Isparta, Turkey between March 2012 and May 2013. Sixty-one symptomatic children (range 7-18 years) with H. pylori infection were randomized to 2 groups: group 1 received standard triple therapy (lansoprazole, amoxicillin, and clarithromycin for 14 days), group 2 received the standard triple therapy plus probiotics (Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium lactis). Side effects of the drugs were recorded. The 14C-urea breath test was performed for 6 weeks after discontinuation of the therapy. Helicobacter pylori infection was detected in 61 of 95 (64.2%) children. Fifty-six patients (38 girls and 18 boys) completed the study. Their mean age was 13.9 ± 2.7 years. Helicobacter pylori eradication rate was 68.9% in group 1, and 66.6% in group 2 (p=0.78). No statistically significant difference was observed between the 2 groups in terms of side effects. We found no evidence in terms of eradicati...Continue Reading

Citations

Oct 27, 2015·Expert Review of Anti-infective Therapy·Carlo CaffarelliGiampaolo Ricci
Feb 6, 2016·Iranian Journal of Pediatrics·Kokab NamkinFatemeh Basirinejad
Sep 16, 2015·Helicobacter·Eleftheria Roma, Erasmo Miele
Mar 16, 2017·Journal of Digestive Diseases·Xin Yan Zhu, Fei Liu
Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Su Young KimJun-Won Chung

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