PMID: 1214226Dec 1, 1975Paper

The effects of prolactin and oxytocin on milk secretion and on the permeability of the mammary epithelium in the rabbit

The Journal of Physiology
J L LinzellJ C Taylor

Abstract

The effects of prolactin or oxytocin on milk secretion and the permeability of the mammary epithelium have been investigated in rabbits. 2. Milk yield was increased by prolactin treatment in late (25-28 days) but not in established (11-14 days) lactation. 3. Prolactin treatment increased milk [lactose] and [K] and decreased [Na] and [Cl] in late lactation, and thus reversed the normal changes in late lactation, but had no significant effect in established lactation. 4. [14C]sucrose movements from blood to milk were significantly decreased to levels characteristic of established lactation, following prolactin treatment in late lactation. No significant effect was evident with treatment in established lactation. Na and Cl movements showed similar trends. 5. It is suggested that prolactin in some way affects paracellular movements of ions and small molecules like lactose across the mammary epithelium, and that this mechanism is responsible for the changes in the composition of the aqueous phase of milk. 6. Immediately following a single dose of 100 m-u. oxytocin no significant effects on milk composition were evident but after 1 u. milk [Na] and [cl] were significantly increased. 7. Twenty-four hr after 1 u. oxytocin, milk [Na] an...Continue Reading

Citations

Nov 20, 2013·Journal of Mammary Gland Biology and Neoplasia·Kerst Stelwagen, Kuljeet Singh
Feb 9, 2007·Journal of Mammary Gland Biology and Neoplasia·Darryl HadsellDaniel Torres
Jun 1, 1977·Kidney International·A D Macknight
Jan 18, 2014·General and Comparative Endocrinology·Jason P BrevesRolf O Karlstrom
Mar 26, 2014·Tissue Barriers·Mark B OwensAnn M Hopkins
Jul 1, 1980·Zentralblatt für Veterinärmedizin. Reihe A·K A AldeenS A Bashar
Jul 14, 2000·Physiological Reviews·D B Shennan, M Peaker
Jul 10, 2001·American Journal of Physiology. Cell Physiology·S BlaugS S Miller
Aug 15, 2017·Journal of Animal Science·C FarmerH Quesnel
Sep 12, 2018·Domestic Animal Endocrinology·C FarmerR C Hovey
Mar 1, 1981·The American Journal of Physiology·C A Bisbee
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·K R Nicholas, P E Hartmann
Jan 26, 2011·Pediatrics·Camille E PoweCorrine K Welt

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