The effects of prolonged controlled hypotension induced by prostaglandin E1 on renal tubular function

Journal of Anesthesia
M FukusakiY Gotoh

Abstract

The effects of the prolonged 3-hour and 6-hour controlled hypotension induced by prostaglandin E(1) (PGE(1)) on renal tubular function have been comparatively studied with trimethaphan (TMP; 3-hour hypotensive anesthesia) and enflurane deep anesthesia (6-hour hypotensive anesthesia), using the urine N-acetyl-Beta-D-glucosaminidase (NAG index) and the serum and urine Beta(2)-microglobulin (fractional clearance of Beta(2)-m; Fc-Beta(2)-m) as markers. During 3-hour and 6-hour controlled hypotension PGE(1), NAG index and Fc-Beta(2)-m and urine volume could be maintained without remarkable changes. In the group with TPM, NAG index and Fc-Beta(2)-m significantly increased. The increasing trend was also noted over time in deep anesthesia with enflurane. On 1st postoperative day, Fc-Beta(2)-m significantly increased in PGE(1) group in both 3-hour and 6-hour hypotensive anesthesia, whereas it restored to normal on 2nd postoperative day. Also, in TMP and enflurane deep anesthesia, Fc-Beta(2)-m significantly increased on 1st postoperative day. With the latter, significant increase was also observed on 2nd postoperative day. These results suggest that, in 3-hour and 6-hour controlled hypotension induced by PGE(1), renal tubular function is...Continue Reading

References

Jan 1, 1977·International Anesthesiology Clinics·K P Geevarghese
Aug 16, 1975·British Medical Journal·J M WellwoodN F Jones
Jan 1, 1972·Scandinavian Journal of Urology and Nephrology·B G Johansson, U Ravnskov
Jan 1, 1973·Nephron·L WibellI Berggård
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P CresswellR T Kubo
Aug 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·I A SatinoverR F Albrecht
Oct 1, 1983·Bulletin of Environmental Contamination and Toxicology·K S Rao, K V Rao
Jan 1, 1980·Head & Neck Surgery·C F WardJ Waldman

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