The effects of propofol, isoflurane and sevoflurane on vecuronium infusion rates for surgical muscle relaxation in dogs

Veterinary Anaesthesia and Analgesia
Shotaro NagahamaNobuo Sasaki

Abstract

To compare the constant rate infusion (CRI) of vecuronium required to maintain a level of neuromuscular blockade adequate for major surgeries, e.g. thoracotomy or laparotomy, in dogs anaesthetized with a CRI of fentanyl and either propofol, isoflurane or sevoflurane. Prospective, randomized, cross-over study. Thirteen male beagles (age, 9-22 months; body mass 6.3-11.3 kg). Dogs were anaesthetized with propofol (24 mg kg(-1) hour(-1) IV CRI; group P), isoflurane (1.3% end-tidal concentration; group I) or sevoflurane (2.3% end-tidal concentration; group S) with fentanyl (5 microg kg(-1) hour(-1) IV, CRI). Sixty to seventy minutes after induction of anaesthesia, vecuronium was administered at a rate of 0.4, 0.3 and 0.2 mg kg(-1) hour(-1) in groups P, I and S respectively. To determine the degree of neuromuscular block, a peripheral nerve was stimulated electrically using the train-of-four (TO4) stimulus pattern. Evoked muscle contractions were evaluated using a neuromuscular monitoring device. Once the TO4 ratio reached 0, the continuous infusion rate was decreased and adjusted to maintain a TO4 count of 1. Continuous infusion was continued for 2 hours. The infusion rate of vecuronium was recorded 20, 40, 60, 80, 100 and 120 minut...Continue Reading

References

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Citations

Jan 6, 2009·Veterinary Anaesthesia and Analgesia·Farshid Sarrafzadeh-Rezaei, R Eddie Clutton
May 10, 2008·Veterinary Anaesthesia and Analgesia·Asadollah Kariman, R Eddie Clutton
Apr 24, 2014·Veterinary Anaesthesia and Analgesia·Manuel Martin-FloresR D Gleed
Feb 25, 2015·American Journal of Veterinary Research·Manuel Martin-FloresRobin D Gleed

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