The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep

Anesthesia and Analgesia
M BookeD L Traber

Abstract

Sepsis is characterized by myocardial depression and systemic vasodilation, both of which are most likely mediated by nitric oxide. Propofol inhibits nitric oxide synthase and may therefore be beneficial in sepsis. On the other hand, renal blood flow, known to be only minimally affected by propofol in healthy subjects, may be drastically reduced in septic individuals, because the renal microvasculature is known to be very sensitive to nitric oxide. In this study, the effects of propofol in healthy and in septic sheep, and in combination with fentanyl, were analyzed and compared with nonanesthetized septic sheep. In healthy sheep, propofol caused only minor hemodynamic changes. In septic sheep, however, hemodynamics deteriorated. Renal blood flow was reduced to 60% +/- 10% of the preseptic baseline and to 39% +/- 4% of the septic value. This reduction was selective, since the cardiac output decreased significantly less. These adverse effects of propofol on hemodynamics and renal blood flow were reduced when propofol was combined with fentanyl.

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Citations

May 27, 2008·Journal of Anesthesia·Noboru TodaYoshio Hatano
Nov 12, 2002·The Journal of Emergency Medicine·Paul E MarikRobert Fromm
May 16, 2000·Critical Care Medicine·T TaniguchiT Kobayashi
May 16, 2000·Critical Care Medicine·M L Ault
Aug 10, 2011·Clinical and Experimental Pharmacology & Physiology·Wen-Yao CuiTao Bai
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergStanislao Morgera
Apr 28, 2006·Kidney International·C LangenbergR Bellomo
Jun 23, 2009·Vascular Pharmacology·Yu LiuMingsheng Zhang
Oct 16, 2015·BMC Veterinary Research·Wonhye LeeSeung-Schik Yoo

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