Abstract
Sepsis is characterized by myocardial depression and systemic vasodilation, both of which are most likely mediated by nitric oxide. Propofol inhibits nitric oxide synthase and may therefore be beneficial in sepsis. On the other hand, renal blood flow, known to be only minimally affected by propofol in healthy subjects, may be drastically reduced in septic individuals, because the renal microvasculature is known to be very sensitive to nitric oxide. In this study, the effects of propofol in healthy and in septic sheep, and in combination with fentanyl, were analyzed and compared with nonanesthetized septic sheep. In healthy sheep, propofol caused only minor hemodynamic changes. In septic sheep, however, hemodynamics deteriorated. Renal blood flow was reduced to 60% +/- 10% of the preseptic baseline and to 39% +/- 4% of the septic value. This reduction was selective, since the cardiac output decreased significantly less. These adverse effects of propofol on hemodynamics and renal blood flow were reduced when propofol was combined with fentanyl.
References
Oct 1, 1992·British Journal of Anaesthesia·R M PuttickW A Ryder
Nov 1, 1992·Anesthesiology·W K ParkR A Johns
Nov 1, 1992·Anesthesiology·E F IsmailG J Crystal
Dec 1, 1991·The American Journal of Physiology·J G WongD E Johnson
Oct 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J SimonsR J Ruane
Feb 1, 1991·Anaesthesia·A GaussO H Wilder-Smith
Apr 1, 1991·British Journal of Anaesthesia·K M VermeyenH F Adriaensen
Sep 1, 1990·British Journal of Anaesthesia·W B RuncimanD G Selby
Sep 1, 1990·British Journal of Anaesthesia·D G SelbyW B Runciman
Sep 1, 1990·British Journal of Anaesthesia·L E MatherW B Runciman
Jan 1, 1990·Nephron·B L RaynerM D Pascoe
Jun 1, 1990·Anesthesia and Analgesia·S G De HertH F Adriaensen
Aug 1, 1989·Anaesthesia·A C MoffatW Fitch
Jan 1, 1988·Anesthesiology·H Van AkenP Lawin
Feb 1, 1983·British Journal of Anaesthesia·H K AdamJ W Dundee
Nov 15, 1993·Biochemical and Biophysical Research Communications·K L MacNaul, N I Hutchinson
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
Jan 1, 1994·Journal of Applied Physiology·J A SpathK H Albertine
Aug 1, 1993·Anaesthesia·A S PhillipsP Elliott
May 1, 1993·British Journal of Pharmacology·A J PetrosJ D Pearson
Jan 1, 1993·Anesthesiology·P S Pagel, D C Warltier
Apr 1, 1993·Journal of Applied Physiology·S NoshimaD L Traber
Citations
May 27, 2008·Journal of Anesthesia·Noboru TodaYoshio Hatano
Oct 2, 2003·European Journal of Pharmacology·Cheng-Ming TsaoChin-Chen Wu
Nov 12, 2002·The Journal of Emergency Medicine·Paul E MarikRobert Fromm
Feb 6, 1999·Critical Care Medicine·M BookeD L Traber
May 16, 2000·Critical Care Medicine·T TaniguchiT Kobayashi
May 16, 2000·Critical Care Medicine·M L Ault
Aug 10, 2011·Clinical and Experimental Pharmacology & Physiology·Wen-Yao CuiTao Bai
Sep 3, 2005·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergStanislao Morgera
Apr 28, 2006·Kidney International·C LangenbergR Bellomo
Oct 18, 2015·Life Sciences·Chih-Yang ChangYing-Hsien Kao
Jun 23, 2009·Vascular Pharmacology·Yu LiuMingsheng Zhang
Oct 16, 2015·BMC Veterinary Research·Wonhye LeeSeung-Schik Yoo
Apr 18, 2009·Anesthesia and Analgesia·Ping-Liang YangBin Liu
May 31, 2001·Anesthesiology·K MikawaH Obara
Dec 3, 2016·Anesthesiology·Lukas LannemyrSven-Erik Ricksten