The effects of propofol on neural and endothelial control of in situ rat mesenteric vascular smooth muscle transmembrane potentials

Anesthesia and Analgesia
Mitsuaki YamazakiT A Stekiel

Abstract

We indirectly assessed the in vivo effect of propofol on sympathetic neural and endothelial control of vascular smooth muscle (VSM) tone in Sprague-Dawley rats by measurement of in situ responses of VSM transmembrane potential (E(m)) in intact, small mesenteric arteries and veins superfused with physiologic salt solution. Measurements were made before, during, and after propofol infusion (10 and 30 mg x kg(-1) x h(-1)) in sympathetically innervated and locally denervated vessels. Propofol's effect on E(m) response to superfusion with acetylcholine (ACh), in physiologic salt solution also containing NG-nitro-L-arginine-methyl-ester and indomethacin, was determined in innervated vessels. At 30 mg x kg(-1) x h(-1), propofol caused greater arterial VSM hyperpolarization in innervated compared with denervated vessels (4.8 +/- 2.0 mV versus 2.8 +/- 1.5 mV, respectively). ACh hyperpolarized arterial, but not venous, VSM (e.g., 11.7 +/- 2.4 mV at 10(-4) M). ACh-induced hyperpolarization was eliminated by 30 mg x kg(-1) x h(-1) propofol. Assuming a close inverse correlation between magnitude of VSM E(m) and contractile force, these results suggest that propofol attenuates both sympathetic neural and nonneural regulation of VSM tone. The...Continue Reading

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·G SiegelG Stock
Jun 1, 1992·Anesthesia and Analgesia·M MuziT J Ebert
Jul 1, 1990·The American Journal of Physiology·M T NelsonN B Standen
Oct 1, 1995·British Journal of Anaesthesia·K KamitaniY Momose
Jan 1, 1995·Trends in Pharmacological Sciences·C J GarlandT M Cocks
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
Mar 1, 1993·Journal of Vascular Research·K L Christensen, M J Mulvany
Jan 15, 1999·Acta Physiologica Scandinavica·N B Standen, J M Quayle
Jul 28, 1999·Anesthesiology·C SchmidtJ I Poelaert

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Citations

Nov 25, 2003·Anesthesia and Analgesia·Tamotsu NagakawaThomas A Stekiel
Jun 23, 2012·Journal of the Chinese Medical Association : JCMA·Cheng-Ming TsaoChin-Chen Wu
May 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ferrante S Gragasin, Sandra T Davidge

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