The effects of propofol on the 40-Hz auditory steady-state response and on the electroencephalogram in humans

Anesthesia and Analgesia
G Plourde

Abstract

The auditory steady-state response (ASSR) is a nearly sinusoidal electrical response of the brain to auditory stimuli delivered at fast rates. The amplitude of the response is largest for stimulus rates near 40/s, hence the label 40-Hz ASSR. We have studied the effects of propofol (1.5 mg/kg) on the 40-Hz ASSR in 14 patients. The spectral edge frequency (SEF) and median frequency (MDF) of the electroencephalogram were recorded for comparison. The study was limited to 6 min after the injection of propofol. Recordings were obtained every minute. Consciousness, defined as responsiveness to verbal command, was assessed in all patients within 1 min. Nine patients, regained consciousness before the end of the study. Propofol caused disappearance of the 40-Hz ASSR for 2 min. Th 40-Hz ASSR reappeared afterward, reaching, at the end of the study period, an amplitude of about 65% of baseline. Recovery of the 40-Hz ASSR occurred whether or not consciousness was regained during the study, but the amplitude tended to be larger in patients who had regained consciousness compared with patients still unconscious during the same recording. The SEF was reduced by 24% within 2 min and recovered more quickly than the 40-Hz ASSR, reaching 91% of ba...Continue Reading

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Citations

May 9, 2000·Pharmacology & Therapeutics·M A WhittingtonR D Traub
Apr 26, 2006·Best Practice & Research. Clinical Anaesthesiology·G Plourde
Dec 29, 1998·AORN Journal·S M Ouellette, C Simpson
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tae KimRobert W McCarley
May 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Aaron J KromYuval Nir

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