The effects of prostacyclin on glycemia and insulin release in man

Prostaglandins
A SzczeklikR Nizankowski

Abstract

Prostacyclin /PGI2/ administered intra-arterially or intravenously to patients with peripheral vascular disease exerted a hyperglycemic effect. In normoglycemic patients receiving PGI2 at a dose of 5 ng/kg/min these effects were barely detectable, but they became unmasked by a rapid glucose injection. In diabetic patients the same PGI1 dose led to distinct elevation in blood glucose. Prostacyclin at a dose of 10 ng/kg/min raised blood glucose levels both at rest and after stimulation with glucose, and opposed effectively hypoglycemic action of tolbutamide in non-diabetic patients. PGI2 repressed glucose-induced insulin release in some normoglycemic patients but in others it either increased it or did not affect it. While hyperglycemic effects are reversible when PGI2 infusion is stopped, and do not interfere with the usual therapeutic administration of prostacyclin for a few days they, nevertheless, might constitute a risk in a patient with poorly controlled diabetes.

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Citations

Jul 1, 1980·Thrombosis Research·A SzczeklikR Korbut
Mar 1, 1981·Prostaglandins·C PatronoS Chierchia
Jan 1, 1981·Prostaglandins·A Dembińska-KiećT Zelazny
Oct 19, 2013·Pharmacology & Therapeutics·David MontaniMarc Humbert
Aug 21, 2015·Expert Opinion on Pharmacotherapy·Swanny PerrinOlivier Sitbon
Nov 17, 2010·Expert Opinion on Drug Metabolism & Toxicology·Marie-Camille ChaumaisDavid Montani
Dec 15, 2007·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Michał Szpinda
Feb 1, 1986·Journal of Clinical Pharmacology·O I LinetC A Greenwald
Jan 31, 2017·Journal of Cell Communication and Signaling·Bethany A CarboneauMaureen Gannon
Aug 1, 1982·British Journal of Clinical Pharmacology·H Pickles, J O'Grady

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