The effects of prostacyclin (PGI2) and 6-keto-PGF1 alpha on bovine plasma progesterone and LH concentrations

Prostaglandins
R A Milvae, W Hansel

Abstract

Injections of 1 mg PGI2 directly into the bovine corpus luteum significantly increased peripheral plasma progesterone concentrations within 5 min. Concentrations were higher in the PGI2-treated heifers than in saline-injected controls between 5 and 150 min and at 3.5, 4, 5, and 7 h post-treatment. Levels tended to remain elevated through 14 h. Saline and 6-keto-PGF1 alpha were without effect on plasma progesterone levels. The luteotrophic effect of PGI2 was not due to alterations in circulating LH concentrations. An in vitro experiment assessed the effects of either PGI2 alone or in combination with LH on progesterone production by dispersed luteal cells. Progesterone accumulation over 2 h for control, 5 ng LH, 1 microgram PGI2, 10 micrograms PGI2, and 10 micrograms PGI2 plus 5 ng LH averaged 99 +/- 42, 353 +/- 70, 152 +/- 35, 252 +/- 45, and 287 +/- 66 ng/ml (n = 4), respectively. Thus PGI2 has luteotrophic effects on the bovine CL both in vivo and in vitro.

References

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Oct 1, 1978·Prostaglandins·E F EllisR P Rubin
Aug 1, 1979·European Journal of Pharmacology·C P QuilleyJ C McGiff
Dec 7, 1979·European Journal of Pharmacology·P Y WongW H Lee
Jan 1, 1977·Prostaglandins·F F SunJ C McGuire
Jul 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·K R SimmonsG D Niswender

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Citations

May 1, 1996·Theriogenology·R A MilvaeJ C Carlson
Jan 1, 1991·Annals of the New York Academy of Sciences·L HambergerP Sjöblom
May 28, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·S E UlbrichH H D Meyer
Jan 22, 2004·Molecular Reproduction and Development·Noritoshi KawateTsutomu Sawada
Mar 1, 1986·Journal of Dairy Science·M F Smith
Jan 5, 2000·Physiological Reviews·G D NiswenderE W McIntush

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