The effects of prostaglandin E2 on pregnancy and embryonic development in mice.

Toxicology
T V Persaud

Abstract

The prostaglandins comprise an important and unique group of naturally occurring biological regulators. These substances are currently being widely used for the induction of labor and termination of pregnancy. The effects of prostaglandin E2 (PGE2) on pregnancy and embryonic development were investigated in Swiss-Webster mice. PGE2 induced a high incidence of abnormal offspring in mice when administered subcutaneously on either day 9, 12 or 15 of gestation. In addition, fetal growth was significantly affected following treatment with the prostaglandin on either the 12th or 15th day of gestation.

References

Dec 12, 1974·The New England Journal of Medicine·L Milkovich, B J van den Berg

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Citations

Dec 1, 1988·Prostaglandins·R F AntonH C Becker
Jan 1, 1981·Progress in Lipid Research·D R Hilbelink, T V Persaud
Oct 1, 1982·Prostaglandins, Leukotrienes, and Medicine·T W Suzanski, T V Persaud
Mar 1, 1985·Prostaglandins, Leukotrienes, and Medicine·B Liebgott, M J Wiley
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·T V Persaud
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·C L Randall, J L Saulnier
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·C L RandallJ L Cook
Oct 6, 1997·Alcoholism, Clinical and Experimental Research·J D ReynoldsJ F Brien
Jul 8, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E CebralM A de Gimeno
Dec 1, 1994·Drug and Alcohol Dependence·R PadmanabhanM B Craigmyle
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·C L RandallH C Becker
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J A PetrereF A de la Iglesia
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J A PetrereF A de la Iglesia
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot

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