PMID: 6992176Jan 1, 1980Paper

The effects of prostaglandins E2 and I2, and arachidonic acid on vascular reactivity to norepinephrine in isolated rat mesenteric artery, hind limb and splenic artery

Prostaglandins and Medicine
K KondoT Saruta

Abstract

The effects of prostaglandins E2 (PGE2) and I2 (PGI2), arachidonic acid, and indomethacin on the vascular reactivity to norepinephrine were tested in three different isolated rat vascular beds (mesenteric artery, hind limb and splenic artery) perfused with the Krebs bicarbonate solution. In these vascular beds PGE2 (0.25--16 ng/ml), PGI2 (0.1--100 ng/ml), arachidonic acid (0.1--10 micrograms/ml) or indomethacin (5--25 micrograms/ml) in the perfusate did not change the basal pressure. In the splenic artery, both PGE2 and PGI2 attenuated the vascular response to norepinephrine in a dose-related manner. In the mesenteric vascular bed and the hind limb, however, PGE2 potentiated the vascular response to norepinephrine, while PGI2 attenuated this response. Acahidonic acid, a prostaglandin precursor, potentiated the vasoconstrictor response to norepinephrine in the mesenteric artery and the hind limb, whereas in the splenic artery, attenuation of the response to norepinephrine occurred. In these three vascular beds, indomethacin, a prostaglandin synthetase inhibitor, attenutated the vascular response to norepinephrine. In the mesenteric artery and the hind limb, PGE2 and not PGI2 reversed the effect of indomethacin, while in the sple...Continue Reading

References

Jul 14, 1978·Biochemical and Biophysical Research Communications·M S MankuW E Barnette
Sep 9, 1977·Biochemical and Biophysical Research Communications·N L BaenzigerP W Majerus

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Citations

Oct 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·K P DavyW G Herbert
Aug 1, 1991·Respiration Physiology·P KaapaJ Anderson
Feb 24, 2001·Journal of Autonomic Pharmacology·H A Peredo, E Adler-Graschinsky
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Katsuhiko NoguchiMatao Sakanashi
Aug 9, 2002·Journal of Cellular and Molecular Medicine·Cristina VidulescuL. M. Popescu
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P HadházyK Magyar
Mar 10, 1998·Thyroid : Official Journal of the American Thyroid Association·J B StanburyG Medeiros-Neto
Sep 4, 2019·British Journal of Pharmacology·Chen Huei LeoLaura J Parry

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