PMID: 3747496Jul 1, 1986Paper

The effects of prosthetic gallstones on gallbladder function and bile composition

The Journal of Surgical Research
I S PomeranzE A Shaffer

Abstract

Diminished gallbladder emptying has been implicated in the pathogenesis of gallstone formation. This study assessed the effect of the physical presence of inert, prosthetic gallstones on gallbladder contractility, histopathology, and bile composition. Three glass beads, each 3 mm in diameter, were implanted in the guinea pig gallbladder. Six weeks later the in vitro contractility was assessed in response to cholecystokinin. Sham-operated animals underwent cholecystotomy without bead implantation. The gross and microscopic appearance of gallbladders from sham-operated and implanted animals was the same. The presence of stones moderately inhibited gallbladder contraction reaching 20.5% (P less than 0.05) at the maximally effective dose of cholecystokinin compared to sham-operated animals. Sham-operated and control (unoperated) animals had similar gallbladder contractility. Thus surgery itself did not alter gallbladder motility. The presence of stones had no effect on biliary lipid composition. It thus appears that gallstones, in the unobstructed gallbladder, cause only a moderate inhibition of gallbladder contractility and have little effect on biliary physiology.

References

Jan 1, 1978·The Journal of Surgical Research·O G Thurston
May 1, 1977·The Journal of Clinical Investigation·E A Shaffer, D M Small
Mar 1, 1984·American Journal of Obstetrics and Gynecology·E A ShafferB Corenblum
May 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·F NAKAYAMA, C G JOHNSTON

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Citations

Nov 1, 1992·Baillière's Clinical Gastroenterology·A Lanzini, T C Northfield
Jul 1, 1989·Journal of Gastroenterology and Hepatology·J N Baxter
May 1, 1990·Gut·P A GraceR C Williamson
Nov 1, 1989·Journal of Hepatology·A Lanzini, T C Northfield
Dec 29, 2017·Current Opinion in Gastroenterology·Agostino Di CiaulaPiero Portincasa
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·P PortincasaG Palasciano
Apr 12, 2000·European Journal of Clinical Investigation·P PortincasaG Palasciano
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·P PortincasaG P van Berge-Henegouwen
Oct 23, 2018·F1000Research·Agostino Di Ciaula, Piero Portincasa

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