PMID: 6169393Sep 28, 1981Paper

The effects of protein deprivation on the nucleus raphe dorsalis: a morphometric Golgi study in rats of three age groups

Brain Research
S Díaz-CintraPeter J Morgane

Abstract

In a previous study we identified 3 cell types in the nucleus raphe dorsalis (NRD): fusiform, multipolar and ovoid. In the present study, we have investigated the effect of an 8% casein diet on these 3 cell types using quantitative techniques on rapid Golgi-impregnated neurons from rats of 3 different ages: 30, 90 and 220 days. Major and minor axes of the cell body and dendritic diameter were unaffected and primary dendritic linear extent was only slightly affected by the diet. All 3 cell types in control rats showed an increase in synaptic spines on both primary and secondary dendrites between 30 and 90 days followed by a decrease for all 3 of the cell types at 220 days. Protein-deprived rats failed to show these age-related changes. Other parameters of comparison showed clear differences between the 3 cell types. These differences could be readily seen when total synaptic spine input to the primary and secondary dendrites was calculated from the data on dendritic number, linear extent and spine density. When viewed in this way the fusiform and ovoid cells show either little change or a decreased synaptic input at all ages, while the presumed serotonergic multipolar cells showed an increase. This is in agreement with neurochem...Continue Reading

References

Aug 1, 1979·The American Journal of Anatomy·D L Felten, K A Crutcher
Sep 1, 1979·The Journal of Comparative Neurology·D L Felten, J P Cummings
May 17, 1973·Brain Research·G M ClarkL Kruger
Oct 10, 1980·Science·D Purves, J W Lichtman

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Citations

Jun 1, 1983·Electroencephalography and Clinical Neurophysiology·J D BronzinoP J Morgane
Jun 1, 1985·Brain Research·W A Debassio, T L Kemper
Dec 1, 1989·Brain Research. Developmental Brain Research·K IshimuraT Kusunoki
Apr 25, 2003·Brain Research. Developmental Brain Research·David J MoklerPeter J Morgane
Jan 22, 2013·ACS Chemical Neuroscience·Rodrigo Andrade, Samir Haj-Dahmane
Jan 12, 2010·Molecular Genetics and Metabolism·Kevin A StraussD Holmes Morton
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·P J MorganeJ R Galler
Mar 31, 2011·Pharmacology & Therapeutics·Lynette C Daws, Georgianna G Gould
Feb 1, 1990·The Journal of Comparative Neurology·S Díaz-CintraP J Morgane
Aug 15, 1991·The Journal of Comparative Neurology·S Diáz-CintraP J Morgane
Oct 4, 2008·Biology Letters·Luis M ChiappeZhonghe Zhou

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