PMID: 38475May 25, 1979

The effects of psychomotor stimulants on single-spatial alternation behavior in dogs

Psychopharmacology
M E Risner, B E Jones

Abstract

Dogs were trained to pedal press for drinking water in a noncued, single-spatial alternation task. After the dogs were exhibiting stable performance at or above predetermined criteria levels, they were given three doses of four different drugs (methylphenidate, 0.2, 0.4, and 0.8 mg/kg; d-amphetamine, 0.15, 0.3 and 0.6 mg/kg; cocaine, 0.5, 1, and 2 mg/kg; and phenmetrazine, 0.6, 1.2 and 2.4 mg/kg). In general, all four drugs produced similar changes in performance. The number of correct responses was an especially sensitive indicator of drug effects. All four drugs also produced significant increases in both the average response latency and total session duration, but there were few significant changes in either the total number of responses or number of intertrial interval responses. Relative to d-amphetamine, the potencies of cocaine and phenmetrazine, but not methylphenidate, were generally higher for the measures of single-spatial alternation than for self-administration.

References

Jan 1, 1980·Psychopharmacology·M E Risner, B E Jones
Jan 1, 1981·Psychopharmacology·M E Risner, D L Silcox
Apr 19, 2003·The Veterinary Clinics of North America. Small Animal Practice·Walter F Burghardt

Citations

Jan 1, 1975·The American Journal of Orthopsychiatry·Sherwood O Cole
Sep 17, 1975·Psychopharmacologia·M E Risner, B E Jones
Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·G A HeiseR A Martin
Aug 1, 1973·The American Journal of Psychiatry·W E FannI C Wilson

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