PMID: 9187988Jun 1, 1997Paper

The effects of pulsatile cardiopulmonary bypass on cerebral and renal blood flow in dogs

Journal of Cardiothoracic and Vascular Anesthesia
D J CookR C Daly

Abstract

The purpose of this study was to determine the effects of pulsatility on cerebral blood flow, cerebral metabolism, and renal blood flow over a range of cardiopulmonary bypass temperature and flow conditions. The investigation was prospective, randomized, and performed in a canine physiology laboratory at the Mayo Foundation. Anesthetized dogs were studied during pulsatile (n = 9) or nonpulsatile (n = 10) cardiopulmonary bypass at two flow rates (2.4 and 1.2 L/min/m2) at each of three temperatures (37 degrees, 32 degrees, and 27 degrees C). Pulsatility was achieved by use of a pediatric intraaortic balloon pump. Cerebral blood flow and metabolic rate were determined using the sagittal sinus outflow method. Renal blood flow was determined by a periarterial ultrasonic flow probe. In the pulsatile group, a pulse pressure of 29 mmHg had no effect on cerebral blood flow or metabolism at any temperature under either flow condition. Renal blood flow was also unaffected by pulsatility, but decreased with hypothermia and reduced pump flow. Pulsatility also did not attenuate the systemic effects of normothermic hypoperfusion. Pulsatility has no significant effect on cerebral or renal perfusion over a broad range of cardiopulmonary bypass ...Continue Reading

References

Mar 1, 1989·The Journal of Thoracic and Cardiovascular Surgery·A R CastanedaJ E Mayer
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J WaabenB Husum
Dec 1, 1983·The Annals of Thoracic Surgery·P R HickeyD M Philbin
Sep 1, 1993·The Annals of Thoracic Surgery·M P AnstadtJ E Lowe

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Citations

Feb 24, 2001·The Annals of Thoracic Surgery·U S BostonD J Cook
Mar 1, 1997·The Annals of Thoracic Surgery·I MacVeighD E Munnikhuysen
Aug 6, 1998·The Annals of Thoracic Surgery·W PlöchlR C Daly
May 9, 2000·The Annals of Thoracic Surgery·H SungurtekinD J Cook
Oct 3, 2006·Current Opinion in Anaesthesiology·P Colson
Apr 22, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andrew H SmithMary B Taylor
Jul 10, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kuk Hui SonKwang Taik Kim
Apr 20, 2005·Blood Purification·Mustafa KocakulakErhan Pişkin
Aug 23, 2001·The Annals of Thoracic Surgery·J M SlaterD J Cook
Jul 29, 1999·The Journal of Thoracic and Cardiovascular Surgery·F KawaharaN Fujita
May 30, 1998·The Journal of Thoracic and Cardiovascular Surgery·B L LiamR C Daly
Jul 13, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·Dennis D Doblar
Jun 5, 1999·Anesthesia and Analgesia·D J Cook
Mar 20, 2015·Anesthesia and Analgesia·Aaron E BarryMartin J London
Apr 29, 2000·Acta Anaesthesiologica Scandinavica·G GrubhoferA Lassnigg
May 19, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Bettina Jungwirth, Fellery de Lange

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