The effects of rabeprazole on parietal cells and enterochromaffin-like cells in rats: a comparison with omeprazole

Journal of Gastroenterology
A TariG Kajiyama

Abstract

We investigated the effects of rabeprazole compared with those of omeprazole on enterochromaffin-like cells and parietal cells in rats. Rabeprazole or omeprazole was administered for 7 days by intraperitoneal injection (100 mg/kg or 20mg/kg once a day) and the serum gastrin concentration, the antral density of G cells and D cells, fundic histamine content, fundic H+, K+-ATPase mRNA level, and parietal cell morphology were determined. Both rabeprazole and omeprazole inhibited gastric acid secretion and increased the intragastric pH to over 6.5, as well as causing a marked increase in the serum gastrin concentration. The serum gastrin level was lower with rabeprazole treatment than with omeprazole treatment at both doses. Also, the antral G-cell density was higher with omeprazole than with rabeprazole, while the increase in both the histamine content and the H+, K-ATPase mRNA level in the fundic mucosa was higher with omeprazole treatment at both doses, with the difference being significant at 100 mg/kg. Ultrastructural examination indicated that the stimulation of parietal cells by omeprazole was stronger than that by rabeprazole. Rabeprazole treatment does not drive enterochromaffin-like cells and parietal cells as strongly as ...Continue Reading

Citations

Dec 4, 2003·European Journal of Pharmacology·Tomoyuki YokotaMorikazu Onji
Feb 28, 2015·Journal of Pharmaceutical Sciences·Yohei KosugiNobuyuki Amano
Apr 14, 2005·European Journal of Gastroenterology & Hepatology·Guido RindiUNKNOWN European Rabeprazole Study Group

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