The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy

Journal of Clinical Anesthesia
Semra DemirbilekZeynep Baysal

Abstract

To compare the effects of remifentanil with alfentanil as a part of total intravenous anesthesia (TIVA) on plasma concentrations of cortisol, insulin, and glucose, and hemodynamic responses in patients undergoing abdominal hysterectomy. Randomized, double-blind study. University hospital. 24 ASA physical status I female patients scheduled for abdominal hysterectomy. Premedicated patients were randomly allocated to receive either remifentanil-propofol (Group R) or alfentanil-propofol (Group A). The loading dose of the study drug was administered over 60 seconds (remifentanil l microg kg(-l) or alfentanil 10 microg kg(-l)) followed by a continuous infusion (remifentanil 0.2 microg kg(-l) min(-l) or alfentanil 0.5 microg kg(-l) min(-l)). In both groups, propofol was administered until loss of consciousness and maintained with a propofol infusion rate of 100 microg kg(-l) min(-l). After induction of anesthesia, all patients were manually ventilated by mask with O2-air mixture for 20 minutes. Then rocuronium 0.6 mg kg(-l) was given for tracheal intubation. Mean arterial pressure (MAP) and heart rate (HR) were recorded. Plasma concentrations of cortisol, insulin, and glucose were measured during anesthesia and in the recovery room. I...Continue Reading

References

Mar 1, 1994·British Journal of Anaesthesia·T A CrozierD Kettler
Aug 6, 2000·British Journal of Anaesthesia·J P Desborough
Aug 23, 2000·Current Opinion in Obstetrics & Gynecology·R MaranaE Marana

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Citations

Nov 10, 2007·Anaesthesia·R KomatsuC C Apfel
May 2, 2014·Acta Anaesthesiologica Scandinavica·N KambeY M Tsutsumi
Feb 10, 2006·Clinical and Vaccine Immunology : CVI·Joseph M FuentesAntonio De Maio
Jan 8, 2008·Neurosurgery·Chad D ColeWilliam T Couldwell
Apr 6, 2020·British Journal of Anaesthesia·Kathirvel SubramaniamVinay Badhwar

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